中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 36 Issue 9
Sep.  2020
Turn off MathJax
Article Contents

Histological prediction of clinical endpoints of liver cirrhosis

DOI: 10.3969/j.issn.1001-5256.2020.09.003
Research funding:

 

  • Received Date: 2020-05-05
  • Published Date: 2020-09-20
  • Patients with liver cirrhosis have different clinical manifestations and prognoses,and it is necessary to accurately predict the clinical endpoints of liver cirrhosis. Liver pathology can directly display the change in liver structure and thus plays an important role in predicting clinical endpoints. This article summarizes the application of histological staging systems and parameters in predicting clinical endpoints and describes the significance of histological features after etiological treatment in predicting clinical prognosis.

     

  • loading
  • [1] GARCIA-TSAO G,FRIEDMAN S,IREDALE J,et al. Now there are many(stages)where before there was one:In search of a pathophysiological classification of cirrhosis[J].Hepatology,2010,51(4):1445-1449.
    [2] RODRGUEZ-DAZ JL,ROSAS-CAMARGO V,VEGA-VEGA O,et al. Clinical and pathological factors associated with the development of hepatocellular carcinoma in patients with hepatitis virus-related cirrhosis:A long-term follow-up study[J]. Clin Oncol(R Coll Radiol),2007,19(3):197-203.
    [3] KIM MY,CHO MY,BAIK SK,et al. Histological subclassification of cirrhosis using the Laennec fibrosis scoring system correlates with clinical stage and grade of portal hypertension[J].J Hepatol,2011,55(5):1004-1009.
    [4] KIM G,LEE SS,BAIK SK,et al. The need for histological subclassification of cirrhosis:A systematic review and meta-analysis[J]. Liver Int,2016,36(6):847-855.
    [5] WANG W,LI J,PAN R,et al. Association of the Laennec staging system with degree of cirrhosis,clinical stage and liver function[J]. Hepatol Int,2015,9(4):621-626.
    [6] KIM SU,OH HJ,WANLESS IR,et al. The Laennec staging system for histological sub-classification of cirrhosis is useful for stratification of prognosis in patients with liver cirrhosis[J].J Hepatol,2012,57(3),556-563.
    [7] KIM SU,JUNG KS,LEE S,et al. Histological subclassification of cirrhosis can predict recurrence after curative resection of hepatocellular carcinoma[J]. Liver Int,2014,34(7):1008-1017.
    [8] NAGULA S,JAIN D,GROSZMANN RJ,et al. Histologicalhemodynamic correlation in cirrhosis-a histological classification of the severity of cirrhosis[J]. J Hepatol,2006,44(1):111-117.
    [9] RIPOLL C,GROSZMANN RJ,GARCIA-TSAO G,et al. Hepatic venous pressure gradient predicts development of hepatocellular carcinoma independently of severity of cirrhosis[J].J Hepatol,2009,50(5):923-928.
    [10] RIPOLL C,GROSZMANN R,GARCIA-TSAO G,et al. Hepatic venous pressure gradient predicts clinical decompensation in patients with compensated cirrhosis[J]. Gastroenterology,2007,133(2):481-488.
    [11] ROSKAMS T,BAPTISTA A,BIANCHI L,et al. Histopathology of portal hypertension:Apractical guideline[J]. Histopathology,2003,42(1):2-13.
    [12] WU QM,ZHAO XY,YOU H. Quantitative fibrosis parameters highly predict esophageal-gastro varices in primary biliary cirrhosis[J]. Eur Rev Med Pharmacol Sci,2016,20(6):1037-1043.
    [13] XU S,WANG Y,TAI DCS,et al. qFibrosis:A fully-quantitative innovative method incorporating histological features to facilitate accurate fibrosis scoring in animal model and chronic hepatitis B patients[J]. J Hepatol,2014,61(2):260-269.
    [14] CALVARUSO V,BURROUGHS AK,STANDISH R,et al. Computer-assisted image analysis of liver collagen:Relationship to Ishak scoring and hepatic venous pressure gradient[J].Hepatology,2009,49(4):1236-1244.
    [15] MANOUSOU P,DHILLON AP,ISGRO G,et al. Digital image analysis of liver collagen predicts clinical outcome of recurrent hepatitis C virus 1 year after liver transplantation[J]. Liver Transpl,2011,17(2):178-188.
    [16] TSOCHATZIS E,BRUNO S,ISGRO G,et al. Col agen proportionate area is superior to other histological methods for subclassifying cirrhosis and determining prognosis[J]. J Hepatol,2014,60(5):948-954.
    [17] MANOUSOU P,BURROUGHS AK,TSOCHATZIS E,et al.Digital image analysis of collagen assessment of progression of fibrosis in recurrent HCV after liver transplantation[J]. J Hepatol,2013,58(5):962-968.
    [18] CO爦AR AM,YAKAR T,SERIN E,et al. The relationship between fibrosis and nodule structure and esophageal varices[J]. Turk J Gastroenterol,2019,30(7):624-629.
    [19] van LEEUWEN DJ,HOWE SC,SCHEUER PJ,et al. Portal hypertension in chronic hepatitis:Relationship to morphological changes[J]. Gut,1990,31(3):339-343.
    [20] COLMAN JC,BRITTON RS,ORREGO H,et al. Relation between osmotically induced hepatocyte enlargement and portal hypertension[J]. Am J Physiol,1983,245(3):g382-g387.
    [21] BLENDIS LM,ORREGO H,CROSSLEY IR,et al. The role of hepatocyte enlargement in hepatic pressure in cirrhotic and noncirrhotic alcoholic liver disease[J]. Hepatology,1982,2(5):539-546.
    [22] DONATO MF,AROSIO E,DEL NINNO E,et al. High rates of hepatocellular carcinoma in cirrhotic patients with high liver cell proliferative activity[J]. Hepatology,2001,34(3):523-528.
    [23] ZHOU P,XIA J,ZHOU YJ,et al. Proportions of acetyl-histone-positive hepatocytes indicate the functional status and prognosis of cirrhotic patients[J]. World J Gastroenterol,2015,21(21):6665-6674.
    [24] SUN Y,ZHOU J,WANG L,et al. New classification of liver biopsy assessment for fibrosis in chronic hepatitis B patients before and after treatment[J]. Hepatology,2017,65(5):1438-1450.
    [25] LEE HW,NA K,KIM SU,et al. Predictive validation of qualitative fibrosis staging in patients with chronic hepatitis B on antiviral therapy[J]. Sci Rep,2019,9(1):15628.
    [26] BEDOSSA P. Reversibility of hepatitis B virus cirrhosis after therapy:Who and why?[J]. Liver Int,2015,35(Suppl 1):78-81.
    [27] FLEMING KE,WANLESS IR. Glutamine synthetase expression in activated hepatocyte progenitor cells and loss of hepatocellular expression in congestion and cirrhosis[J]. Liver Int,2013,33(4):525-534.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (1180) PDF downloads(116) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return