中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 36 Issue 8
Aug.  2020
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Article Contents

Research advances in the pathogenesis of nonalcoholic fatty liver disease

DOI: 10.3969/j.issn.1001-5256.2020.08.043
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  • Published Date: 2020-08-20
  • The development and progression of nonalcoholic fatty liver disease(NAFLD) have complex potential mechanisms.The traditional“two-hit”pathophysiological theory has been challenged,and in recent years,an increasing number of studies have been performed to investigate the interaction between insulin resistance,adipokines,and other unknown pathogenic factors in various organs.This article summarizes the factors of the liver,intestinal tract,hypothalamus,and extracellular cysts,as well as genetic factors,with an emphasis on the synergistic mechanism of action of the liver and extrahepatic organs in the pathogenesis of NAFLD,in order to provide a reference for obtaining new insights into NAFLD regulatory network and determining new targets for the prevention and treatment of NAFLD.

     

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