中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 36 Issue 8
Aug.  2020
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Article Contents

Role of the VEGF/VEGFR pathways in the development,progression,and treatment of cholangiocellular carcinoma

DOI: 10.3969/j.issn.1001-5256.2020.08.041
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  • Published Date: 2020-08-20
  • Cholangiocellular carcinoma(CCA) is a malignant tumor derived from the biliary epithelium,with a lack of effective therapeutic drugs and poor prognosis.Studies have shown that the development and progression of CCA are closely associated with angiogenesis,and a variety of angiogenic factors,including vascular endothelial growth factor(VEGF) and its receptor VEGFR,can regulate angiogenesis in CCA,participate in the development and progression of CCA,and affect its prognosis.Therefore,anti-angiogenic drugs targeting VEGF/VEGFR,such as monoclonal antibodies and small-molecule inhibitors,have gradually become research hotspots for the treatment of CCA.This article reviews the role of the VEGF/VEGFR pathways in the clinical features and prognosis of CCA,the advances in anti-angiogenic therapy for CCA,and related studies on drug resistance.

     

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