中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 36 Issue 7
Jul.  2020
Turn off MathJax
Article Contents

Risk factors for hepatitis B virus-related hepatocellular carcinoma

DOI: 10.3969/j.issn.1001-5256.2020.07.041
Research funding:

 

  • Published Date: 2020-07-20
  • At present,hepatitis B virus( HBV) infection is recognized as an important risk factor for hepatocellular carcinoma( HCC) in the world; however,during the development and progression of hepatitis B,liver cirrhosis,and liver cancer,other factors may promote the development of HCC independently or synergistically with HBV,such as sex,age,family history,alanine aminotransferase/aspartate aminotransferase,smoking and drinking history,metabolic syndrome,and HCV or HIV infection. This article reviews the research advances in the risk factors associated with HCC.

     

  • loading
  • [1]KANDA T,GOTO T,HIROTSU Y,et al.Molecular mechanisms driving progression of liver cirrhosis towards hepatocellular carcinoma in chronic hepatitis B and C infections:A review[J].Int J Mol Sci,2019,20(6):1358.
    [2]THI VT,POOVORAWAN K,HAROEN P,et al.Association between hepatitis B surface antigen levels and the risk of hepatocellular carcinoma in patients with chronic hepatitis B infection:Systematic review and Meta-analysis[J].Asian Pac J Cancer Prev,2019,20:2239-2246.
    [3]LEE MH,YANG HI,LIU J,et al.Prediction models of long-term cirrhosis and hepatocellular carcinoma risk in chronic hepatitis B patients:Risk scores integrating host and virus profiles[J].Hepatology,2013,58(2):546-554.
    [4]WONG KH,CHENG CY,LUNG Y,et al.Among patients with undetectable hepatitis B surface antigen and hepatocellular carcinoma,a high proportion has integration of HBV DNA into hepatocyte DNA and no cirrhosis[J].Clin Gastroenterol Hepatol,2020,18(2):449-456.
    [5]CHEN YC,CHU CM,LIAW YF.Age-specific prognosis following spontaneous hepatitis B e antigen seroconversion in chronic hepatitis B[J].Hepatology,2010,51(2):435-44.
    [6]CHANG MH,HSU HY,HSU HC,et al.The significance of spontaneous hepatitis B e antigen seroconversion in childhood:With special emphasis on the clearance of hepatitis B e antigen before 3 years of age[J].Hepatology,1995,22(5):1387-1392.
    [7]XIE YH.Hepatitis B virus-associated hepatocellular carcinoma[J].Adv Exp Med Biol,2017,1018:11-21:365.
    [8]BUDZINSKA MA,SHACKEL NA,URBAN S,et al.Cellular genomic sites of hepatitis B virus DNA integration[J].Genes(Basel),2018,9(7).
    [9]WITJES CD,IJZERMANS JN,van der EIJK AA,et al.Quantitative HBV DNA and AST are strong predictors for survival after HCC detection in chronic HBV patients[J].Neth J Med,2011,69(11):508-513.
    [10]CHEN X,WU F,LIU Y,et al.The contribution of serum hepatitis Bvirus load in the carcinogenesis and prognosis of hepatocellular carcinoma:Evidence from two meta-analyses[J].Oncotarget,2016,7(31):49299-49309.
    [11]LIN CL,KAO JH.The clinical implications of hepatitis B virus genotype:Recent advances.[J].J Gastroenterol Hepatol,2011,26(Suppl 1):123-130.
    [12]LIU CJ,KAO JH.Global perspective on the natural history of chronic hepatitis B:Role of hepatitis B virus genotypes A to J[J].Semin Liver Dis,2013,33(2):97-102.
    [13]PINATO DJ,DALLA PRIA A,SHARMA R,et al.Hepatocellular carcinoma:An evolving challenge in viral hepatitis and HIV coinfection[J].AIDS,2017,31(5):603-611.
    [14]RUGGIERI A,GAGLIARDI MC,ANTICOLI S.Sex-dependent outcome of hepatitis B and C viruses infections:Synergy of sex hormones and immune responses?[J].Front Immunol,2018,9:2302.
    [15]BUETTNER N,THIMME R.Sexual dimorphism in hepatitis B and Cand hepatocellular carcinoma[J].Semin Immunopathol,2019,41(2):203-211.
    [16]ZHA XD,LIU WB,CAO GW.Risk factors related to the sexual dimorphism in the incidence and prognosis of hepatocellular carcinoma[J].Shanghai J Prev Med,2017,29(4):253-256.(in Chinese)查旭东,刘文斌,曹广文.肝细胞癌发生及预后性别差异的相关危险因素[J].上海预防医学,2017,29(4):253-256.
    [17]YANG SJ,LI LJ,REN H.Epidemiology(8th edition)[M].Beijing:People's Medical Publishing House,2013.(in Chinese)杨绍基,李兰娟,任红.传染病学(第八版)[M].北京:人民卫生出版社,2013.
    [18]YIP TC,CHAN HL,WONG VW,et al.Impact of age and gender on risk of hepatocellular carcinoma after hepatitis B surface antigen seroclearance[J].J Hepatol,2017,67(5):902-908.
    [19]KIM GA,LEE HC,KIM MJ,et al.Incidence of hepatocellular carcinoma after HBs Ag seroclearance in chronic hepatitis B patients:Aneed for surveillance[J].J Hepatol,2015,62(5):1092-1099.
    [20]LOOMBA R,LIU J,YANG HI,et al.Synergistic effects of family history of hepatocellular carcinoma and hepatitis B virus infection on risk for incident hepatocellular carcinoma[J].Clin Gastroenterol Hepatol,2013,11(12):1636-1645.e1-3.
    [21]WELEDJI EP.Familial hepatocellular carcinoma:'A model for studying preventive and therapeutic measures'[J].Ann Med Surg(Lond),2018,35:129-132.
    [22]AN J,CHANG S,KIM HI,et al.The clinical behavior and survival of patients with hepatocellular carcinoma and a family history of the disease[J].Cancer Med,2019,8(15):6624-6633.
    [23]LIN YJ,LEE MH,YANG HI,et al.Predictability of liver-related seromarkers for the risk of hepatocellular carcinoma in chronic hepatitis B patients[J].PLo S One,2013,8(4):e61448.
    [24]EL-ZAYADI AR.Heavy smoking and liver[J].World J Gastroenterol,2006,12(38):6098-6101.
    [25]ALAVIAN SM,JAZAYERI SM.Commentary on“risk factors for early-onset and late-onset hepatocellular carcinoma in Asian immigrants with hepatitis B in the United States”[J].Am J Gastroenterol,2012,107(4):635.
    [26]LI Y,ZHANG Z,SHI J,et al.Risk factors for naturally-occurring early-onset hepatocellular carcinoma in patients with HBV-associated liver cirrhosis in China[J].Int J Clin Exp Med,2015,8(1):1205-1212.
    [27]IIDA-UENO A,ENOMOTO M,TAMORI A,et al.Hepatitis B virus infection and alcohol consumption[J].World J Gastroenterol,2017,23(15):2651-2659.
    [28]LV X,LIU K,CHEN Y,et al.Analysis of risk factors associated with the development of hepatocellular carcinoma in chronic HBV-infected Chinese:A meta-analysis[J].Int J Environ Res Public Health,2016,13(6):604.
    [29]LIN CW,LIN CC,MO LR,et al.Heavy alcohol consumption increases the incidence of hepatocellular carcinoma in hepatitis B virus-related cirrhosis[J].J Hepatol,2013,58(4):730-735.
    [30]WANG WJ,XIAO P,XU HQ,et al.Growing burden of alcoholic liver disease in China:A review.[J].World J Gastroenterol,2019,25(12):1445-1456.
    [31]LINDENMEYER CC,MCCULLOUGH AJ.The natural history of nonalcoholic fatty liver disease-an evolving view[J].Clin Liver Dis,2018,22(1):11-21.
    [32]TAN Y,ZHANG X,ZHANG W,et al.The influence of metabolic syndrome on the risk of hepatocellular carcinoma in patients with chronic hepatitis B infection in Mainland China[J].Cancer Epidemiol Biomarkers Prev,2019,28(12):2038-2046.
    [33]YU MW,LIN CL,LIU CJ,et al.Influence of metabolic risk factors on risk of hepatocellular carcinoma and liver-related death in men with chronic hepatitis B:A large cohort study[J].Gastroenterology,2017,153(4):1006-1017.e5.
    [34]KUTLU O,KALELI HN,OZER E.Molecular pathogenesis of nonalcoholic steatohepatitis-(NASH-)related hepatocellular carcinoma[J].Can J Gastroenterol Hepatol,2018,2018:8543763.
    [35]POLESEL J,ZUCCHETTO A,MONTELLA M,et al.The impact of obesity and diabetes mellitus on the risk of hepatocellular carcinoma[J].Ann Oncol,2009,20(2):353-357.
    [36]GOH MJ,SINN DH,KIM S,et al.Statin use and the risk of hepatocellular carcinoma in patients with chronic hepatitis B[J].Hepatology,2019.[Online ahead of print]
    [37]ELKRIEF L,RAUTOU PE,SARIN S,et al.Diabetes mellitus in patients with cirrhosis:Clinical implications and management[J].Liver Int,2016,36(7):936-948.
    [38]YOUNOSSI Z,KOCHEMS K,de RIDDER M,et al.Should adults with diabetes mellitus be vaccinated against hepatitis B virus?A systematic review of diabetes mellitus and the progression of hepatitis Bdisease[J].Hum Vaccin Immunother,2017,13(11):2695-2706.
    [39]LI X,XU HQ,GAO PJ.Diabetes mellitus is a risk factor for hepatocellular carcinoma in patients with chronic hepatitis B virus infection in China[J].Med Sci Monit,2018,24:6729-6734.
    [40]CHEUK-FUNG YIP T,WAI-SUN WONG V,LIK-YUEN CHANH,et al.Effects of diabetes and glycemic control on risk of hepatocellular carcinoma after seroclearance of hepatitis B surface antigen[J].Clin Gastroenterol Hepatol,2018,16(5):765-773.e2.
    [41] CHEN HJ,ZHONG NS,LU ZY.Internal medicine(8th edition)[M].Beijing:People's Medical Publishing House,2013.(in Chinese)陈灏珠,钟南山,陆再英.内科学(第八版)[M].北京:人民卫生出版社,2013.
    [42]LI M,NIE QH,HAN M,et al.Risk factors,early screening,and preventing strategy for hepatitis B-related hepatocellular carcinoma[J].J Clin Hepatol,2019,35(3):651-655.(in Chinese)李汨,聂青和,韩曼.HBV相关肝细胞癌的危险因素、早期筛查和预防策略[J].临床肝胆病杂志,2019,35(3):651-655.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (766) PDF downloads(152) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return