中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 36 Issue 2
Feb.  2020
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Article Contents

Programmed necrosis of macrophages plays an important role in liver immune response

DOI: 10.3969/j.issn.1001-5256.2020.02.048
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  • Received Date: 2019-07-29
  • Published Date: 2020-02-20
  • Liver macrophages are in a dynamic equilibrium of immune tolerance and immune response after continuous antigen stimulation.The immune response of liver macrophages to external antigen is closely associated with the immune homeostasis of the liver. This article reviews the association between the programmed necrosis pathway and the apoptotic pathway and elaborates on the important role of the activity of IKK complex in the interactive regulation of the programmed necrosis and apoptotic pathways. Further studies are needed to clarify the role of programmed necrosis in the response of liver macrophages to extrahepatic antigens.

     

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