中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 36 Issue 2
Feb.  2020
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Article Contents

Role of oxidative stress and autophagy in the development and progression of hepatocellular carcinoma

DOI: 10.3969/j.issn.1001-5256.2020.02.042
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  • Received Date: 2019-10-08
  • Published Date: 2020-02-20
  • Hepatocellular carcinoma( HCC) is a primary malignant tumor of the liver and has a complex pathogenesis. At present,the oxidative stress theory is one of the many important theories for the mechanism of the development and progression of this disease. Autophagy is an important way for cells to clear misfolded proteins or damaged organelles and maintain homeostasis of the internal environment. An increasing number of evidence has shown that autophagy plays an important role in liver fibrosis and HCC and is closely associated with oxidative stress. With reference to the latest research findings around the world,this article analyzes the interaction between autophagy and oxidative stress in the pathogenesis of HCC from the aspect of their relationship with HCC. It is pointed out that the molecular mechanism by which autophagy regulates oxidative stress in the development of HCC may become a research hotspot in the future; it may provide a new means for the early diagnosis and treatment of HCC to activate or block a key pathway through which autophagy regulates oxidative stress.

     

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  • [1] DYSON J,JAQUES B,CHATTOPADYHAY D,et al. Hepatocellular cancer:The impact of obesity,type 2 diabetes and a multidisciplinary team[J]. J Hepatol,2014,60(1):110-117.
    [2] HAMID AS,TESFAMARIAM IG,ZHANG Y,et al. Aflatoxin B1-induced hepatocellular carcinoma in developing countries:Geographical distribution,mechanism of action and prevention[J]. Oncol Lett,2013,5(4):1087-1092.
    [3] ZOLLER H,TILG H. Nonalcoholic fatty liver disease and hepatocellular carcinoma[J]. Metabolism,2016,65(8):1151-1160.
    [4] EL-SERAG HB,KANWAL F. Obesity and hepatocellular carcinoma:Hype and reality[J]. Hepatology,2014,60(3):779-781.
    [5] DEVENISH RJ,KLIONSKY DJ. Autophagy:Mechanism and physiological relevance ‘brewed’ from yeast studies[J].Front Biosci(Schol Ed),2012,4:1354-1363.
    [6] WANG MQ,LI YP,LIU LY,et al. Role and mechanism of autophagy in development and progression of hepatocellular carcinoma and regulation of immunotherapy[J]. J Clin Hepatol,2019,35(5):1129-1134.(in Chinese)王沐淇,李亚萍,刘拉羊,等.自噬在肝细胞癌发生发展和免疫治疗调控中的作用及其机制[J].临床肝胆病杂志,2019,35(5):1129-1134.
    [7] LI WX,WANG XC,XIANG MH,et al. Huaier inhibits proliferation and metastasis of liver cancer cells by inducing autophagy[J/CD]. Chin J Hepat Surg(Electronic Edition),2019,8(2):169-174.(in Chinese)黎文信,王喜城,向美焕,等.槐耳通过诱导自噬抑制肝癌细胞增殖与迁移[J/CD].中华肝脏外科手术学电子杂志,2019,8(2):169-174.
    [8] LIN T,SHA YQ,CHEN ZX. Advances in vitro studies on induction of autophagy in hepatocellular carcinoma by active ingredients of traditional Chinese medicine[J]. China Med Herald,2018,15(34):49-52,56.(in Chinese)林彤,沙永强,陈泽雄.中药活性成分诱导肝细胞癌自噬的体外实验研究进展[J].中国医药导报,2018,15(34):49-52,56.
    [9] YAZDANI HO,HUANG H,TSUNG A. Autophagy:Dual response in the development of hepatocellular carcinoma[J].Cells,2019,8(2):91.
    [10] GALLUZZI L,PIETROCOLA F,BRAVO-SAN PEDRO JM,et al.Autophagy in malignant transformation and cancer progression[J]. EMBO J,2015,34(7):856-880.
    [11] WANG X,DENG Q,FENG K,et al. Insufficient radiofrequency ablation promotes hepatocellular carcinoma cell progression via autophagy and the CD133 feedback loop[J]. Oncol Rep,2018,40(1):241-251.
    [12] CICCARONE F,CASTELLI S,CIRIOLO MR. Oxidative stress-driven autophagy acROSs onset and therapeutic outcome in hepatocellular carcinoma[J]. Oxid Med Cell Longev,2019,2019:6050123.
    [13] SAITOH T,FUJITA N,JANG MH,et al. Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production[J]. Nature,2008,456(7219):264-268.
    [14] WANG L,LI H,ZHEN Z,et al. CXCL17 promotes cell metastasis and inhibits autophagy via the LKB1-AMPK pathway in hepatocellular carcinoma[J]. Gene,2019,690:129-136.
    [15] YUE Z,JIN S,YANG C,et al. Beclin 1,an autophagy gene essential for early embryonic development,is a haploinsufficient tumor suppressor[J]. Proc Natl Acad Sci U S A,2003,100(25):15077-15082.
    [16] TAKAMURA A,KOMATSU M,HARA T,et al. Autophagydeficient mice develop multiple liver tumors[J]. Genes Dev,2011,25(8):795-800.
    [17] WU FQ,FANG T,YU LX,et al. ADRB2 signaling promotes HCC progression and sorafenib resistance by inhibiting autophagic degradation of HIF1α[J]. J Hepatol,2016,65(2):314-324.
    [18] LI P,DU Q,CAO Z,et al. Interferon-γinduces autophagy with growth inhibition and cell death in human hepatocellular carcinoma(HCC)cells through interferon-regulatory factor-1(IRF-1)[J]. Cancer Lett,2012,314(2):213-222.
    [19] CHANG Y,YAN W,HE X,et al. miR-375 inhibits autophagy and reduces viability of hepatocellular carcinoma cells under hypoxic conditions[J]. Gastroenterology,2012,143(1):177-187.
    [20] ZHANG H,ZHANG Y,ZHU X,et al. DEAD box protein 5 inhibits liver tumorigenesis by stimulating autophagy via interaction with p62/SQSTM1[J]. Hepatology,2019,69(3):1046-1063.
    [21] ZHAO M,YANG M,YANG L,et al. HMGB1 regulates autophagy through increasing transcriptional activities of JNK and ERK in human myeloid leukemia cells[J]. BMB Rep,2011,44(9):601-606.
    [22] LIU Y,YAN W,TOHME S,et al. Hypoxia induced HMGB1and mitochondrial DNA interactions mediate tumor growth in hepatocellular carcinoma through Toll-like receptor 9[J]. J Hepatol,2015,63(1):114-121.
    [23] SHARIFI MN,MOWERS EE,DRAKE LE,et al. Autophagy promotes focal adhesion disassembly and cell motility of metastatic tumor cells through the direct interaction of paxillin with LC3[J]. Cell Rep,2016,15(8):1660-1672.
    [24] PENG YF,SHI YH,DING ZB,et al. Autophagy inhibition suppresses pulmonary metastasis of HCC in mice via impairing anoikis resistance and colonization of HCC cells[J]. Autophagy,2013,9(12):2056-2068.
    [25] WANG X,ZHANG Y,FENG T,et al. Fluid shear stress promotes autophagy in hepatocellular carcinoma cells[J]. Int J Biol Sci,2018,14(10):1277-1290.
    [26] AQUILANO K,BALDELLI S,CIRIOLO MR. Glutathione:New roles in redox signaling for an old antioxidant[J]. Front Pharmacol,2014,5:196.
    [27] DIAO Y,LIU W,WONG CC,et al. Oxidation-induced intramolecular disulfide bond inactivates mitogen-activated protein kinase kinase 6 by inhibiting ATP binding[J]. Proc Natl Acad Sci U S A,2010,107(49):20974-20979.
    [28] JUNG SY,KIM YJ. C-terminal region of HBx is crucial for mitochondrial DNA damage[J]. Cancer Lett,2013,331(1):76-83.
    [29] PAL S,POLYAK SJ,BANO N,et al. Hepatitis C virus induces oxidative stress,DNA damage and modulates the DNA repair enzyme NEIL1[J]. J Gastroenterol Hepatol,2010,25(3):627-634.
    [30] ARTEEL GE,IIMURO Y,YIN M,et al. Chronic enteral ethanol treatment causes hypoxia in rat liver tissue in vivo[J]. Hepatology,1997,25(4):920-926.
    [31] di LEO L,VEGLIANTE R,CICCARONE F,et al. Forcing ATGL expression in hepatocarcinoma cells imposes glycolytic rewiring through PPAR-α/p300-mediated acetylation of p53[J]. Oncogene,2019,38(11):1860-1875.
    [32] LIM SO,GU JM,KIM MS,et al. Epigenetic changes induced by reactive oxygen species in hepatocellular carcinoma:Methylation of the E-cadherin promoter[J]. Gastroenterology,2008,135(6):2128-2140.
    [33] NI HM,WOOLBRIGHT BL,WILLIAMS J,et al. Nrf2 promotes the development of fibrosis and tumorigenesis in mice with defective hepatic autophagy[J]. J Hepatol,2014,61(3):617-625.
    [34] DU H,YANG W,CHEN L,et al. Emerging role of autophagy during ischemia-hypoxia and reperfusion in hepatocellular carcinoma[J]. Int J Oncol,2012,40(6):2049-2057.
    [35] ZHANG J,NEY PA. Role of BNIP3 and NIX in cell death,autophagy,and mitophagy[J]. Cell Death Differ,2009,16(7):939-946.
    [36] WILLIAMS JA,NI HM,DING Y,et al. Parkin regulates mitophagy and mitochondrial function to protect against alcohol-induced liver injury and steatosis in mice[J]. Am J Physiol Gastrointest Liver Physiol,2015,309(5):g324-g340.
    [37] EID N,ITO Y,HORIBE A,et al. Ethanol-induced mitophagy in liver is associated with activation of the PINK1-Parkin pathway triggered by oxidative DNA damage[J]. Histol Histopathol,2016,31(10):1143-1159.
    [38] MAHLI A,THASLER WE,PATSENKER E,et al. Identification of cytochrome CYP2E1 as critical mediator of synergistic effects of alcohol and cellular lipid accumulation in hepatocytes in vitro[J]. Oncotarget,2015,6(39):41464-41478.
    [39] DASARI SK,BIALIK S,LEVIN-ZAIDMAN S,et al. Signalome-wide RNAi screen identifies GBA1 as a positive mediator of autophagic cell death[J]. Cell Death Differ,2017,24(7):1288-1302.
    [40] HUANG Q,ZHAN L,CAO H,et al. Increased mitochondrial fission promotes autophagy and hepatocellular carcinoma cell survival through the ROS-modulated coordinated regulation of the NFKB and TP53 pathways[J]. Autophagy,2016,12(6):999-1014.
    [41] LI L,CHEN Y,GIBSON SB. Starvation-induced autophagy is regulated by mitochondrial reactive oxygen species leading to AMPK activation[J]. Cell Signal,2013,25(1):50-65.
    [42] DESIDERI E,VEGLIANTE R,CARDACI S,et al. MAPK14/p38α-dependent modulation of glucose metabolism affects ROS levels and autophagy during starvation[J]. Autophagy,2014,10(9):1652-1665.
    [43] BARTOLINI D,DALLAGLIO K,TORQUATO P,et al. Nrf2-p62autophagy pathway and its response to oxidative stress in hepatocellular carcinoma[J]. Transl Res,2018,193:54-71.
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