中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 35 Issue 11
Nov.  2019
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Article Contents

Expression of FAM134B in liver cancer and its association with prognosis: An analysis based on data mining

DOI: 10.3969/j.issn.1001-5256.2019.11.023
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  • Received Date: 2019-06-18
  • Published Date: 2019-11-20
  • Objective To investigate the expression of FAM134 B in liver cancer and its association with clinicopathological features and prognosis. Methods Data mining was performed for Oncomine,Human Protein Atlas,TCGA,and Kaplan Meier-Plotter databases to analyze the expression of FAM134 B in liver cancer,and the association of the expression of FAM134 B with clinicopathological characteristics and prognosis was analyzed. The chi-square test was used for comparison of categorical data between groups,and the Kaplan-Meier method was used to investigate the association between FAM134 B expression and prognosis of liver cancer. Results As for normal tissue,the highest expression level of FAM134 B was found in the kidney,and the expression of FAM134 B in the liver ranked 9 th; as for tumor tissue,the highest expression of FAM134 B was found in renal cancer,and the expression of FAM134 B in liver cancer ranked 11 th. A total of 147 studies found a significant difference in FAM134 B expression,and there was a significant difference in FAM134 B expression between various tumors. FAM134 B expression in liver cancer tissue was lower than that in normal liver tissue. FAM134 B protein was localized in the endoplasmic reticulum,and its expression was associated with age of onset of liver cancer patients,liver cirrhosis,alpha-fetoprotein,race,and degree of tumor differentiation( all P < 0. 05). FAM134 B expression was associated with the overall survival rate of liver cancer patients( hazard ratio [HR]= 0. 67,95% confidence interval[CI]: 0. 47-0. 95,P = 0. 026) and had significant influence on the prognosis of the Asian population( HR = 0. 40,95% CI: 0. 22-0. 74,P = 0. 003),while it had no significant influence on the prognosis of the Caucasian population( HR = 0. 65,95% CI: 0. 40-1. 05,P = 0. 076). Conclusion There is a significant difference in the expression of FAM134 B between tumors,with a low expression in liver cancer. FAM134 B protein is localized in the endoplasmic reticulum,and its low expression is associated with several malignant phenotypes of liver cancer and the low overall survival rate.

     

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