Immunological mechanism of Treg/Th17 and Th1/Th2 balance in autoimmune hepatitis and new targets for diagnosis and treatment

Wang WeiZhao; Xiang XiaoXing

doi:10.3969/j.issn.1001-5256.2019.08.051

Volume 35 Issue 8

Aug. 2019

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Article Navigation > Journal of Clinical Hepatology > 2019 > 35(8): 1874-1877

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Immunological mechanism of Treg/Th17 and Th1/Th2 balance in autoimmune hepatitis and new targets for diagnosis and treatment

DOI: 10.3969/j.issn.1001-5256.2019.08.051

Department of Gastroenterology, Dalian Medical University

Received Date: 2019-02-26
Published Date: 2019-08-20

Abstract

Abstract

Autoimmune hepatitis (AIH) is a chronic autoimmune disease in the liver, with major clinical manifestations of positive autoantibody, abnormal elevation of aminotransferases, and hypergammaglobulinemia. Current studies have shown that regulatory T (Treg) /T helper17 (Th17) and T helper 1 (Th1) /T helper 2 (Th2) imbalance is one of the mechanisms of the development and progression of AIH. OX40 (also known as CD134, TNFRSF4, or ACT35) and its ligand OX40 L are members of the tumor necrosis factor family, and they participate in immune response as co-stimulators of T cell activation and can regulate Treg/Th17 and Th1/Th2 balance, thus affecting the progression of various autoimmune diseases. However, there are few reports on the role of OX40 and OX40 L in AIH. With reference to related articles, this article reviews the role of Treg/Th17 and Th1/Th2 balance in AIH and the potential association between OX40/OX40 L (new targets for immunological diagnosis and treatment) and AIH.
- hepatitis, autoimmune,
- T-lymphocytes, regulatory,
- T-lymphocytes, helper-inducers

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References(39)

References

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Immunological mechanism of Treg/Th17 and Th1/Th2 balance in autoimmune hepatitis and new targets for diagnosis and treatment

DOI: 10.3969/j.issn.1001-5256.2019.08.051

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Immunological mechanism of Treg/Th17 and Th1/Th2 balance in autoimmune hepatitis and new targets for diagnosis and treatment

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