Application status and future prospect of the Gao-Binge model in alcoholic liver disease

The pathogenesis of alcoholic liver disease remains unclear, mainly due to the lack of accurate animal models in experiments.Many different animal models have been established to mimic alcoholic liver disease in patients, which have both advantages and disadvanta-ges. Among these models, the Gao-Binge model is widely used in the experiments because it highly mimics the drinking pattern in patients.It is more persuasive that the pathogenesis and therapeutic drugs have been examined in the Gao-Bingemodel. Although there are some lim-its in the Gao-Binge model, it is no doubt that this model has high value and future prospect in the study of alcoholic liver disease becauseof short duration time, low cost and good repeatability. Finally, the Gao-Binge model has also been used to study alcohol-induced damageto other organs such as the heart, pancreas, adipose tissue etc.