中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 35 Issue 2
Feb.  2019
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Article Contents

Establishment and application of animal models of cholestasis

DOI: 10.3969/j.issn.1001-5256.2019.02.046
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  • Received Date: 2018-10-08
  • Published Date: 2019-02-20
  • Cholestatic liver disease is one of the common diseases in children aged < 1 year and has a complex etiology and different outcomes. Various animal models have been established to further investigate the pathogenesis of cholestatic liver disease and related treatment strategies. A model of obstructive cholestasis is established by surgery or external physical and chemical damage; a model of intrahepatic cholestasis is induced by chemicals or endotoxins, including α-naphthyl isothiocyanate, lipopolysaccharide, 3, 5-diethoxycarbonyl-1, 4-dihydrocollidine, estrogen, chlorpromazine, rifampicin, and lithocholic acid; a model of parenteral nutrition-associated cholestasis is established by a combination of intestinal damage and parenteral nutrition. These models reflect different causes and development processes.This article reviews the characteristics, mechanisms, and indications of animal models of cholestasis commonly used in medical research.

     

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