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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 12
Dec.  2018
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Article Contents

Clinical trials tracking nonalcoholic fatty liver disease: Drug classification

DOI: 10.3969/j.issn.1001-5256.2018.12.002
  • Published Date: 2018-12-20
  • At present, there are still no effective drugs launched for the treatment of nonalcoholic fatty liver disease (NAFLD) , and many drugs are being evaluated in clinical trials. These drugs have different mechanisms of action in treatment, such as improvement of glycolipid metabolism, anti-inflammation, anti-fibrosis, and improvement of intestinal microbiota. This article elaborates on the research and development of drugs from the following aspects: inflammatory response and immune activation, lipid metabolism and insulin resistance, lipotoxicity, oxidative stress, cell apoptosis and necrosis, collagen formation and degradation, and proliferation of intestinal microbiota.

     

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