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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 8
Aug.  2018
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Article Contents

The association between type 2 diabetes mellitus and hepatocellular carcinoma

DOI: 10.3969/j.issn.1001-5256.2018.08.045
  • Received Date: 2018-01-29
  • Published Date: 2018-08-20
  • Type 2 diabetes mellitus ( T2 DM) is closely associated with the development of hepatocellular carcinoma ( HCC) . T2 DM can increase the risk of HCC in many ways, which suggests that several signaling pathways or susceptibility genes might be involved in the development of these two diseases. This article discusses the role of T2 DM in the development of HCC and the association between T2 DM and HCC at genetic and molecular levels and finds that nuclear receptor co-activator 5, transcription factor 7-like 2, glycogen synthase kinase 3β, and Toll-like receptor 4 are involved in the pathogenesis of T2 DM and HCC, which is the key that links the two diseases at genetic and molecular levels.

     

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  • [1]TORRE LA, BRAY F, SIEGEL RL, et al.Global cancer statistics, 2012[J].CA Cancer J Clin, 2015, 65 (2) :87-108.
    [2]Mc GLYNN KA, PETRICK JL, LONDON WT.Global epidemiology of hepatocellular carcinoma:An emphasis on demographic and regional variability[J].Clin Liver Dis, 2015, 19 (2) :223-238.
    [3]WOJCIECHOWSKA J, KRAJEWSKI W, BOLANOWSKI M, et al.Diabetes and cancer:A review of current knowledge[J].Exp Clin Endocrinol Diabetes, 2016, 124 (5) :263-275.
    [4]NAGAOKI Y, HYOGO H, AIKATA H, et al.Recent trend of clinical features in patients with hepatocellular carcinoma[J].Hepatol Res, 2012, 42 (4) :368-375.
    [5]CHEN J, HAN Y, XU C, et al.Effect of type 2 diabetes mellitus on the Risk for hepatocellular carcinoma in chronic liver diseases:A meta-analysis of cohort studies[J].Eur J Cancer Prev, 2015, 24 (2) :89-99.
    [6]LI X, WANG X, GAO P.Diabetes mellitus and risk of hepatocellular carcinoma[J].Biomed Res Int, 2017, 2017:5202684.
    [7]LIANG J, HAN T.Diabetes mellitus and primary liver cancer:Risk factor or real cause?[J].J Clin Hepatol, 2017, 33 (4) :757-762. (in Chinese) 梁静, 韩涛.糖尿病与原发性肝癌:危险因素还是致病病因?[J].临床肝胆病杂志, 2017, 33 (4) :757-762.
    [8]LIU C, ZHANG Z, TANG H, et al.Crosstalk between IGF-1R and other tumor promoting pathways[J].Curr Pharm Des, 2014, 20 (17) :2912-2921.
    [9]JABIR NR, AHMAD S, TABREZ S.An insight on the association of glycation with hepatocellular carcinoma[J].Semin Cancer Biol, 2018, 49:56-63.
    [10]AGOSTI P, SABBAC, MAZZOCCA A.Emerging metabolic risk factors in hepatocellular carcinoma and their influence on the liver microenvironment[J].Biochim Biophys Acta, 2018, 1864 (2) :607-617.
    [11]MO XL, LIU J, ZHU JY, et al.Value of transforming growth factor-β1 in diagnosis of primary liver cancer:A meta-analysis[J].J Clin Hepatol, 2017, 33 (5) :864-868. (in Chinese) 莫晓丽, 刘洁, 诸佳瑜, 等.TGFβ1对原发性肝癌诊断价值的Meta分析[J].临床肝胆病杂志, 2017, 33 (5) :864-868.
    [12]LI XF, CHEN C, XIANG DM, et al.Chronic inflammation-elicited liver progenitor cell conversion to liver cancer stem cell with clinical significance[J].Hepatology, 2017, 66 (6) :1934-1951.
    [13]MITRA A, YAN J, XIA X, et al.IL6-mediated inflammatory loop reprograms normal to epithelial-mesenchymal transition+metastatic cancer stem cells in preneoplastic liver of transforming growth factor beta-deficientβ2-spectrin+/-mice[J].Hepatology, 2017, 65 (4) :1222-1236.
    [14]QIAO B, ZHOU Y, SHI CH, et al.Mechanisms and treatment progress of hepatogenous diabetes[J/CD].Chin J Liver Dis:Electronic Edition, 2016, 8 (3) :21-25. (in Chinese) 乔兵, 周永, 史昌河, 等.肝源性糖尿病诊疗进展[J/CD].中国肝脏病杂志:电子版, 2016, 8 (3) :21-25.
    [15]RUSTEMOGLU A, ERKOL INAL E, INANIR A, et al.Clinical significance of NCOA5 gene rs2903908 polymorphism in Behcet's disease[J].EXCLI J, 2017, 16:609-617.
    [16]PELEKANOU V, KAMPA M, KIAGIADAKI F, et al.Estrogen anti-inflammatory activity on human monocytes is mediated through cross-talk between estrogen receptor ERα36 and GPR30/GPER1[J].J Leukoc Biol, 2016, 99 (2) :333-347.
    [17]NAUGLER WE, SAKURAI T, KIM S, et al.Gender disparity in liver cancer due to sex differences in My D88-dependent IL-6 production[J].Science, 2007, 317 (5834) :121-124.
    [18]FACCIORUSSO A, BARONE M.Glucose intolerance and hepatocellular carcinoma:Recent findings for old diseases[J].Hepatobiliary Surg Nutr, 2014, 3 (2) :91-92.
    [19]GAO S, LI A, LIU F, et al.NCOA5 haploinsufficiency results in glucose intolerance and subsequent hepatocellular carcinoma[J].Cancer Cell, 2013, 24 (6) :725-737.
    [20]LIU X, LIU F, GAO S, et al.A single non-synonymous NCOA5variation in type 2 diabetic patients with hepatocellular carcinoma impairs the function of NCOA5 in cell cycle regulation[J].Cancer Lett, 2017, 391:152-161.
    [21]LEWIS JP, PALMER ND, ELLINGTON JB, et al.Analysis of candidate genes on chromosome 20q12-13.1 reveals evidence for BMI mediated association of PREX1 with type 2 diabetes in European Americans[J].Genomics, 2010, 96 (4) :211-219.
    [22]JIN T.Current understanding on role of the wnt signaling pathway effector TCF7L2 in glucose homeostasis[J].Endocr Rev, 2016, 37 (3) :254-277.
    [23]OSMARK P, HANSSON O, JONSSON A, et al.Unique splicing pattern of the TCF7L2 gene in human pancreatic islets[J].Diabetologia, 2009, 52 (5) :850-854.
    [24]LE BACQUER O, SHU L, MARCHAND M, et al.TCF7L2 splice variants have distinct effects on beta-cell turnover and function[J].Hum Mol Genet, 2011, 20 (10) :1906-1915.
    [25]RIZVI S, RAZA ST, RAHMAN Q, et al.Role of GNB3, NET, KCNJ11, TCF7L2 and GRL genes single nucleotide polymorphism in the risk prediction of type 2 diabetes mellitus[J].3 Biotech, 2016, 6 (2) :255.
    [26]IBRAHIM AT, HUSSAIN A, SALIH MA, et al.Candidate gene analysis supports a role for polymorphisms at TCF7L2 as risk factors for type2 diabetes in Sudan[J].J Diabetes Metab Disord, 2016, 15:4.
    [27]ISHIGURO H, WAKASUGI T, TERASHITA Y, et al.Nuclear expression of TCF4/TCF7L2 is correlated with poor prognosis in patients with esophageal squamous cell carcinoma[J].Cell Mol Biol Lett, 2016, 21:5.
    [28]LING Q, DONG F, GENG L, et al.Impacts of TCF7L2 gene polymorphisms on the susceptibility of hepatogenous diabetes and hepatocellular carcinoma in cirrhotic patients[J].Gene, 2013, 522 (2) :214-218.
    [29]YOUNESS RA, EL-TAYEBI HM, ASSAL RA, et al.MicroRNA-486-5p enhances hepatocellular carcinoma tumor suppression through repression of IGF-1R and its downstream m TOR, STAT3and c-Myc[J].Oncol Lett, 2016, 12 (4) :2567-2573.
    [30]ZENG X, HUANG H, TAMAI K, et al.Initiation of Wnt signaling:Control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions[J].Development, 2008, 135 (2) :367-375.
    [31]AMPUERO J, ROMERO-GOMEZ M.Prevention of hepatocellular carcinoma by correction of metabolic abnormalities:Role of statins and metformin[J].World J Hepatol, 2015, 7 (8) :1105-1111.
    [32]QIU J, FU YF.Glycogen synthase kinase-3 and tumorigenesis[J].J Int Oncol, 2010, 37 (6) :416-419. (in Chinese) 邱建, 傅云峰.糖原合成激酶-3β与肿瘤的发生发展[J].国际肿瘤学杂志, 2010, 37 (6) :416-419.
    [33]VILCHEZ V, TURCIOS L, MARTI F, et al.Targeting Wnt/β-catenin pathway in hepatocellular carcinoma treatment[J].World J Gastroenterol, 2016, 22 (2) :823-832.
    [34]QIAO G, LE Y, LI J, et al.Glycogen synthase kinase-3βis associated with the prognosis of hepatocellular carcinoma and may mediate the influence of type 2 diabetes mellitus on hepatocellular carcinoma[J].PLo S One, 2014, 9 (8) :e105624.
    [35]WU YJ, GUO JS.Hepatic stellate cells, Toll-like receptor 4 signaling pathway, and inflammatory fibrotic microenvironment in the development of hepatocellular carcinoma[J].J Clin Hepatol, 2015, 31 (6) :876-879. (in Chinese) 吴玉婧, 郭津生.肝星状细胞、Toll样受体4信号途径、炎症及纤维化微环境与原发性肝癌发生发展的关系[J].临床肝胆病杂志, 2015, 31 (6) :876-879.
    [36]HWANG DH, KIM JA, LEE JY.Mechanisms for the activation of Toll-like receptor 2/4 by saturated fatty acids and inhibition by docosahexaenoic acid[J].Eur J Pharmacol, 2016, 785:24-35.
    [37]CHEN H, LIU Y, LI D, et al.PGC-1βsuppresses saturated fatty acid-induced macrophage inflammation by inhibiting TAK1 activation[J].IUBMB Life, 2016, 68 (2) :145-155.
    [38]MAMEDOVA LK, YUAN K, LAUDICK AN, et al.Toll-like receptor 4 signaling is required for induction of gluconeogenic gene expression by palmitate in human hepatic carcinoma cells[J].J Nutr Biochem, 2013, 24 (8) :1499-1507.
    [39]DASU MR, DEVARAJ S, PARK S, et al.Increased toll-like receptor (TLR) activation and TLR ligands in recently diagnosed type2 diabetic subjects[J].Diabetes Care, 2010, 33 (4) :861-868.
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