Clinical value of anti-HBc quantification for chronic HBV infection

As the achivement of a major project during the 12 th Five-year Plan Period in China, the technique of anti-HBc quantification has been approved for commercial use and holds promise for wide application in clinical practice. Chinese scholars have explored the clinical significance of anti-HBc in various aspects and found that it has great values in the assessment of natural course of chronic hepatitis B virus ( HBV) infection and the baseline prediction of antiviral therapy. Studies have shown that anti-HBc is significantly positively correlated with alanine aminotransferase ( ALT) and significantly associated with liver inflammation. In chronic HBV infection patients with a normal ALT level, anti-HBc can be used instead as an indicator, with great significance for the development of therapeutic strategy in such patients.