|
[1]GUPTA SC, KISMALI G, AGGARWAL BB.Curcumin, a component of turmeric:from farm to pharmacy[J].Biofactors, 2013, 39 (1) :2-13.
|
|
[2]BASNET P, SKALKO-BASNET N.Curcumin:an anti-inflammatory molecule from a curry spice on the path to cancer treatment[J].Molecules, 2011, 16 (6) :4567-4598.
|
|
[3]REUTER S, EIFES S, DICATO M, et al.Modulation of anti-apoptotic and survival pathways by curcumin as a strategy to induce apoptosis in cancer cells[J].Biochem Pharmacol, 2008, 76 (11) :1340-1351.
|
|
[4]PARK W, AMIN AR, CHEN ZG, et al.New perspectives of curcumin in cancer prevention[J].Cancer Prev Res, 2013, 6 (5) :387-400.
|
|
[5]GOEL A, AGGARWAL BB.Curcumin, the golden spice from indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs[J].Nutr Cancer, 2010, 62 (7) :919-930.
|
|
[6]JACOB JN, BADYAL DK, BALA S, et al.Evaluation of the in vivo anti-inflammatory and analgesic and in vitro anti-cancer activities of curcumin and its derivatives[J].Nat Prod Commun, 2013, 8 (3) :359-362.
|
|
[7]BIMONTE S, BARBIERI A, PALMA G, et al.Curcumin inhibits tumor growth and angiogenesis in an orthotopic mouse model of human pancreatic cancer[J].Biomed Res Int, 2013, 2013:810423.
|
|
[8]KWON YK, JUN JM, SHIN SW, et al.Curcumin decreases cell proliferation rates through BTG2-mediated cyclin D1 down-regulation in U937 cells[J].Int J Oncol, 2005, 26 (6) :1597-1603.
|
|
[9]AGGARWAL BB, BANERJEE S, BHARADWAJ U, et al.Curcumin induces the degradation of cyclin E expression through ubiquitin-dependent pathway and up-regulates cyclin-dependent kinase inhibitors p21 and p27 in multiple human tumor cell lines[J].Biochem Pharmacol, 2007, 73 (7) :1024-1032.
|
|
[10]JANSON V, JOHANSSON A, GRANKVIST K.Resistance to caspase-8 and-9 fragments in a malignant pleural mesothelioma cell line with acquired cisplatin-resistance[J].Cell Death Dis, 2010, 1:e78.
|
|
[11]PU J, LI X, ZHU J, et al.Expression and roles of poly (ADP-ribose) polymerase-1 and caspase-3 in pancreatic cancer and adjacen[J].J Clin Hepatol, 2016, 32 (2) :337-341. (in Chinese) 蒲竞, 李汛, 朱骏, 等.PARP-1和caspase-3在胰腺癌及癌旁组织中的表达及意义[J].临床肝胆病杂志, 2016, 32 (2) :337-341.
|
|
[12]GUPTA SC, PATCHVA S, KOH W, et al.Discovery of curcumin, a component of golden spice, and its miraculous biological activities[J].Clin Exp Pharmacol Physiol, 2012, 39 (3) :283-299
|
|
[13]HATCHER H, PLANALP R, CHO J, et al.Curcumin:from ancient medicine to current clinical trials[J].Cell Mol Life Sci, 2008, 65 (11) :1631-1652.
|
|
[14] REUTER S, EIFES SM, AGGARWAL B, et al.Modulation of anti-apoptotic and survival pathways by curcumin as a strategy to induce apoptosis in cancer cells[J].Biochem Pharmacol, 2008, 76 (76) :1340-1351.
|
|
[15] GLIENKE W, MAUTE L, WICHT J, et al.Curcumin inhibits constitutive STAT3 phosphorylation in human pancreatic cancer cell lines and downregulation of survivin/BIRC5 gene expression[J].Cancer Invest, 2010, 28 (2) :166-171.
|
|
[16]JUTOORU I, CHADALAPAKA G, LEI P, et al.Inhibition of NFκB and pancreatic cancer cell and tumor growth by curcumin is dependent on specificity protein down-regulation[J].J Biol Chem, 2010, 285 (33) :25332-25344.
|
|
[17]JUTOORU I, CHADALAPAKA G, LEI P, et al.Inhibition of NFkappa B and pancreatic cancer cell and tumor growth by curcumin is dependent on specificity protein down-regulation[J].J Biol Chem, 2010, 285 (285) :25332-25344.
|
|
[18]WILKEN R, VEENA MS, WANG MB, et al.Curcumin:a review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma[J].Mol Cancer, 2011, 10:12.
|
|
[19]ABEL EV, KIM EJ, WU J, et al.The Notch pathway is important in maintaining the cancer stem cell population in pancreatic cancer[J].PLo S One, 2014, 9 (3) :e91983.
|
|
[20]DU X, WANG YH, WANG ZQ, et al.Down-regulation of Notch1by small interfering RNA enhances chemosensitivity to gemcitabine in pancreatic cancer cells through activating apoptosis activity[J].J Zhejiang Univ:Med Sci, 2014, 43 (3) :313-318. (in Chinese) 杜潇, 王从涵, 王自强, 等.小分子干扰RNA沉默Notch1后增加胰腺癌细胞凋亡活性而提高吉西他滨化疗敏感性[J].浙江大学学报:医学版, 2014, 43 (3) :313-318.
|
|
[21]SUBRAMANIAM D, NICHOLES N, MAY R, et al.Abstract5046:SR1264, a novel tetrafluoro analog of curcumin prevents pancreatic tumor growth in vivo by suppressing Notch signaling pathway[J].Cancer Res, 2011, 70 (8 Suppl) :5046.
|
|
[22]LI H, HUANG C, HUANG K, et al.STAT3 knockdown reduces pancreatic cancer cell invasiveness and matrix metalloproteinase-7expression in nude mice[J].PLo S One, 2011, 6 (10) :e25941.
|
|
[23]GLIENKE W, MAUTE L, WICHT J, et al.Curcumin inhibits constitutive STAT3 phosphorylation in human pancreatic cancer cell lines and downregulation of survivin/BIRC5 gene expression[J].Cancer Invest, 2010, 28 (2) :166-171.
|
|
[24]YAO Q, LIN M, WANG Y, et al.Curcumin induces the apoptosis of A549 cells via oxidative stress and MAPK signaling pathways[J].Int J Mol Med, 2015, 36 (4) :1118-1126.
|
|
[25]JING L, XIANG ST, ZHANG QH, et al.Combination of curcumin and bicalutamide enhanced the growth inhibition of androgen-independent prostate cancer cells through SAPK/JNK and MEK/ERK1/2-mediated targeting NF-κB/p65 and MUC1-C[J].J Exp Clin Canc Res, 2015, 34 (1) :1-11.
|
|
[26]THAKKAR A, SUTARIA D, GRANDHI K, et al.Abstract A65:activation of ERK1/2 using combination of aspirin, curcumin and sulforaphane regimen leads to NF-B inhibition and apoptosis in pancreatic cancer cells[J].Cancer Prev Res, 2014, 5 (11 Suppl) :a65.
|
|
[27]LEV-ARI S, STARR A, VEXLER A, et al.Inhibition of pancreatic and lung adenocarcinoma cell survival by curcumin is associated with increased apoptosis, down-regulation of COX-2 and EGFR and inhibition of Erk1/2 activity[J].Anticancer Res, 2006, 26 (6B) :4423-4430.
|
|
[28]ZHANG Y, ZHOU YF, HU M.Research progress of traditional Chinese medicine for the invasion and metastasis of hepatocellular carcinoma[J].Chin J Clin pharmacol Ther, 2017, 22 (5) :594-600. (in Chinese) 张颖, 周缓凤, 胡敏.肝癌侵袭转移的中医药研究进展[J].中国临床药理学与治疗学, 2017, 22 (5) :594-600.
|
|
[29]ROY SK, SRIVASTAVA RK, SHANKAR S.Inhibition of PI3K/AKT and MAPK/ERK pathways causes activation of FOXO transcription factor, leading to cell cycle arrest and apoptosis in pancreatic cancer[J].J Mol Signal, 2010, 5:10.
|
|
[30]ZHAO Z, LI C, XI H, et al.Curcumin induces apoptosis in pancreatic cancer cells through the induction of forkhead box O1 and inhibition of the PI3K/Akt pathway[J].Mol Med Rep, 2015, 12 (4) :5415-5422.
|
|
[31]JONSON T, ALBRECHTSSON E, AXELSON J, et al.Altered expression of TGFB receptors and mitogenic effects of TGFB in pancreatic carcinomas[J].Int J Oncol, 2001, 19 (1) :71-81.
|
|
[32]OSHIMA M, OKANO K, MURAKI S, et al.Immunohistochemically detected expression of 3 major genes (CDKN2A/p16, TP53, and SMAD4/DPC4) strongly predicts survival in patients with resectable pancreatic cancer[J].Ann Surg, 2013, 258 (2) :336-346.
|
|
[33]GU ZY, LI SY, XIAO ZW, et al.The anti-tumor effect and mechanism of curcumin in pancreatic cancer[J].Tianjin Med J, 2014, 42 (12) :1159-1162. (in Chinese) 谷倬宇, 李思源, 肖智伟, 等.姜黄素的抗胰腺癌作用及相关机制研究[J].天津医药, 2014, 42 (12) :1159-1162.
|
|
[34]FRYER R, LABARTHE MC, DALGLEISH A, et al.The novel anti-cancer agent curcumin induces cytotoxicity in pancreatic cancer cell lines in vitro[J].Cancer Res, 2008, 68:5673-5673.
|
|
[35]MORRIS JP, WANG SC, HEBROK M.KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma[J].Nat Rev Cancer, 2010, 10 (10) :683-695.
|
|
[36]ZHANG Y, YAN W, SCHOFIELD HK, et al.Canonical wnt signaling is required for pancreatic carcinogenesis[J].Cancer Res, 2013, 73 (15) :4909-4922.
|
|
[37]AHN J, LEE H, KIM S, et al.Curcumin-induced suppression of adipogenic differentiation is accompanied by activation of Wnt/beta-catenin signaling[J].Am J Physiol Cell Physiol, 2010, 298 (6) :1510-1516.
|
|
[38]CHEN YC, ZHOU B, CHEN XM, et al.Effect of curcumin on the human colon cancer cells SW480[J].Chin J Clin Pharmacol Ther, 2017, 22 (5) :526-530. (in Chinese) 陈永财, 周斌, 陈雪敏, 等.姜黄素靶向抑制SW480细胞信号通路研究[J].中国临床药理学与治疗学, 2017, 22 (5) :526-530.
|
|
[39]LI SH, FU J, WATKINS DN, et al.Sulforaphane regulates selfrenewal of pancreatic cancer stem cells through the modulation of Sonichedgehog-GLI pathway[J].Mol Cell Biochem, 2013, 373 (1-2) :217-227.
|
|
[40]MAGLIANO MPD, HEBROK M.Hedgehog signaling pathways in pancreatic cancer pathogenesis[M].New York:Springer, 2010.
|
|
[41]SUN XD, LIU XE.Curcumin induces apoptosis of pancreatic cancer cells by inhibiting Ras-ERK and Shh-GLI1 signal pathways[J].Chin J Pathophysiol, 2012, 28 (6) :996-1000. (in Chinese) 孙晓东, 刘杏娥.姜黄素通过抑制Ras-ERK和Shh-GLI1信号诱导胰腺癌细胞凋亡[J].中国病理生理杂志, 2012, 28 (6) :996-1000.
|
|
[42]ELAMIN MH, SHINWARI Z, HENDRAYANI SF, et al.Curcumin inhibits the Sonic Hedgehog signaling pathway and triggers apoptosis in medulloblastoma cells[J].Mol Carcinog, 2010, 49 (3) :302-314.
|
|
[43]EL-AZAB M, HISHE H, MOUSTAFA Y, et al.Anti-angiogenic effect of resveratrol or curcuminin Ehrlichascites carcinomabearingmice[J].Eur J Pharmacol, 2011, 652 (1-3) :7-14.
|
|
[44]WEY JS, FAN FBS, GRAY MJ, et al.Vascular endothelial growth factor receptor-1 promotes migration and invasion in pancreatic carcinoma cell lines[J].Cancer, 2005, 104 (2) :427-438.
|
|
[45]SYLVESTER J, LIACINI A, WEN QL, et al.Interleukin-17 signal transduction pathways implicated in inducing matrix metalloproteinase-3, -13 and aggrecanase-1 genes in articular chondrocytes[J].Cell Signal, 2004, 16 (4) :469-476.
|
|
[46]ALI S, AHMAD AS, PADHYE S, et al.Gemcitabine sensitivity can be induced in pancreatic cancer cells through modulation of miR-200 and miR-21 expression by curcumin or its analogue CDF[J].Cancer Research, 2010, 70 (9) :3606-3617.
|
|
[47]BAI MH, ZHANG Y, WANG BF, et al.Mechanism of curcuminenhanced radiosensitivity in pancreatic cancer cells PANC-1[J].Chin J Radiol Med Prot, 2013, 33 (4) :360-363. (in Chinese) 白明华, 张扬, 王宝峰, 等.姜黄素提高人胰腺癌PANC-1细胞放射敏感性的机制研究[J].中华放射医学与防护杂志, 2013, 33 (4) :360-363.
|
|
[48]GONG AX, GUAN FL, LIU M, et al.Effects of curcumin combined with nimesulide on pancreatic cancer cells[J].Chin J Dig, 2005, 25 (1) :48-49. (in Chinese) 宫爱霞, 关凤林, 刘敏, 等.姜黄素与尼美舒利联合应用对胰腺癌细胞的作用[J].中华消化杂志, 2005, 25 (1) :48-49.
|
|
[49]KURIEN BT, SCOFIELD RH.Oral administration of heat-solubilized curcumin for potentially increasing curcumin bioavailability in experimental animals[J].Int J Cancer, 2009, 125 (8) :1992-1993.
|
DownLoad: