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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 4
Apr.  2018
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Article Contents

Role of the nuclear factor-kappa B signaling pathway on the progress of hepatic fibrosis and the anti-fibrotic mechanism of traditional Chinese medicine

DOI: 10.3969/j.issn.1001-5256.2018.04.035
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  • Received Date: 2017-10-31
  • Published Date: 2018-04-20
  • Nuclear factor-kappa B (NF-κB) plays an important role in various physiological and pathological processes by regulating gene expression, such as cell survival, growth, proliferation, activation, and apoptosis.In particular, the NF-κB signaling pathway has an important regulatory effect on the progression of hepatic fibrosis.This article reviews the structure and function of NF-κB, the regulatory effect of NF-κB on hepatocytes, Kupffer cells, and hepatic stellate cells in the progression of hepatic fibrosis, and the anti-fibrotic mechanism of traditional Chinese medicine by regulating the activity of the NF-κB signaling pathway.We also point out the complex interaction between NF-κB and various types of cells in certain diseases and emphasize the clinical significance of traditional Chinese medicine in inhibiting the activity of NF-κB and alleviating hepatic fibrosis.

     

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