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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 2
Feb.  2018
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Article Contents

Association between estrogen receptor gene polymorphisms and the development and progression of hepatocellular carcinoma

DOI: 10.3969/j.issn.1001-5256.2018.02.047
  • Published Date: 2018-02-20
  • The development and progression of hepatocellular carcinoma (HCC) is associated with estrogen, which exerts its physiological effect by binding to estrogen receptor (ER) .The function of ER is regulated by related genes, while the expression and function of these genes are affected by gene polymorphisms, and the genetic susceptibility to tumors is due to the combined effect of different genes and polymorphisms.Therefore, it is believed that ER gene polymorphisms may affect the development, progression, and prognosis of HCC.This article reviews the research advances in ER gene polymorphisms in recent years.

     

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  • [1]LI Z, TUTEJA G, SCHUG J, et al.Foxa1 and Foxa2 are essential for sexual dimorphism in liver cancer[J].Cell, 2012, 148 (1-2) :72-83.
    [2]HEFAIEDH R, ENNAIFER R, ROMDHANE H, et al.Gender difference in patients with hepatocellular carcinoma[J].Tunis Med, 2013, 91 (8-9) :505-508.
    [3]WANG AG, LEE KY, KIM SY, et al.The expression of estrogen receptors in hepatocellular carcinoma in Korean patients[J].Yonsei Med J, 2006, 47 (6) :811-816.
    [4]WANG JS.Clinical significance and changes of serum sex hormone levels in patients with hepatocellular carcinoma[J].Chin J Prim Med Pharm, 2014, 21 (6) :836-837. (in Chinese) 王劲松.原发性肝癌患者血清性激素水平变化及临床意义[J].中国基层医药, 2014, 21 (6) :836-837.
    [5]ZOU JL, TANG C, MO XQ.Animal experiments of the role of sex hormones in the liver cancer[J].China Prac Med, 2012, 7 (22) :23-24. (in Chinese) 邹劲林, 汤聪, 莫湘琼.性激素在肝癌发生中作用的动物实验[J].中国实用医药, 2012, 7 (22) :23-24.
    [6]VILLA E.Role of estrogen in liver cancer[J].Womens Health (Lond) , 2008, 4:41-50.
    [7]KALRA M, Mayes J, ASSEFA S, et al.Role of sex steroid receptors in pathobiology of hepatocellular carcinoma[J].World J Gastroenterol, 2008, 14 (39) :5945-5961.
    [8] JEMAL A, BRAY F, CENTER MM, et al.Global cancer statistics[J].CA Cancer J Clin, 2011, 61 (2) :69-90.
    [9]EL-SERAG HB, RUDOLPH KL.Hepatocellular carcinoma:epidemiology and molecular carcinogenesis[J].Gastroenterology, 2007, 132 (7) :2557-2576.
    [10]LUO XL, TAN WT, ZHOU Y, et al.Expression of estrogen receptorsαandβin hepatitis B virus-related hepatocellular carcinoma and clinical significance[J].J Third Milit Med Univ, 2014, 36 (6) :564-567. (in Chinese) 罗晓丽, 谭文婷, 周媛, 等.ERα及ERβ在HBV相关肝细胞癌中的表达及临床意义[J].第三军医大学学报, 2014, 36 (6) :564-567.
    [11]SHIMIZU I.Impact of oestrogens on the progression of liver disease[J].Liver Int, 2003, 23 (1) :63-69.
    [12]SHIMIZU I, INOUE H, YANO M, et al.Estrogen receptor levels and lipid peroxidation in hepatocellular carcinoma with hepatitis C virus infection[J].Liver, 2001, 21 (5) :342-349.
    [13]DEY P, BARROS RP, WARNER M, et al.Insight into the mechanisms of action of estrogen receptorβin the breast, prostate, colon, and CNS[J].J Mol Endocrinol, 2013, 51 (3) :t61-t74.
    [14]BOONYARATANAKORNKIT V, EDWARDS DP.Receptor mechanisms mediating non-genomic actions of sex steroids[J].Semin Reprod Med, 2007, 25 (3) :139-153.
    [15]LIU JF, HE Q, ZHOU JW, et al.The value of estrogen receptor alpha expression in the liver tissue in the pathological diagnosis of liver cancer[J].Shandong Med J, 2015, 55 (44) :61-62. (in Chinese) 刘俊峰, 何琼, 周建文, 等.肝组织雌激素受体α表达在肝癌病理诊断中的价值[J].山东医药, 2015, 55 (44) :61-62.
    [16]ZHANG Y, JI HM, SHEN YC, et al.Expression and significance of sex hormone receptors in hepatocellular carcinoma and adjacent normal tissues[J].Chin Gen Pract, 2012, 15 (33) :3851-3855. (in Chinese) 张燕, 吉浩明, 沈预程, 等.性激素受体在肝癌患者癌组织和癌旁组织中的表达及意义[J].中国全科医学, 2012, 15 (33) :3851-3855.
    [17]AHMED HH, SHOUSHA WG, SHALBY AB, et al.Implications of sex hormone receptor gene expression in the predominance of hepatocellular carcinoma in males:role of natural products[J].Asian Pac J Cancer Prev, 2015, 16 (12) :4949-4954.
    [18]DAI B, GENG L, YU Y, et al.Methylation patterns of estrogen receptorαpromoter correlate with estrogen receptorαexpression and clinicopathological factors in hepatocellular carcinoma[J].Exp Biol Med (Maywood) , 2014, 239 (7) :883-890.
    [19]NILSSON M, NAESSEN S, DAHLMAN I, et al.Association of estrogen receptor beta gene polymorphisms with bulimic disease in women[J].Mol Psychiatry, 2004, 9 (1) :28-34.
    [20]SUN H, HOU J, SHI W, et al.Estrogen receptor 1 (ESR1) genetic variations in cancer risk:a systematic review and meta-analysis[J].Clin Res Hepatol Gastroenterol, 2015, 39 (1) :127-135.
    [21]YIN ZN, LIU W, WANG JW.Correlation between serum markers and polymorphism of Apo AI-75Msp I gene in patients with type B hepatitis[J].Int J Lab Med, 2012, 33 (3) :276-277, 280. (in Chinese) 尹志农, 刘薇, 王俊文.乙型肝炎感染者血清标志物与Apo AI-75Msp I基因多态性的相关性研究[J].国际检验医学杂志, 2012, 33 (3) :276-277, 280.
    [22]SHASTRY BS.SNP alleles in human disease and evolution[J].J Hum Genet, 2002, 47 (11) :561-566.
    [23]SOBCZAK K, KRZYZOSIAK WJ.Patterns of CAG repeat interruptions in SCA1 and SCA2 genes in relation to repeat instability[J].Hum Mutat, 2004, 24 (3) :236-247.
    [24]SETIAWAN VW, HANKINSON SE, COLDITZ GA, et al.Estrogen receptor beta (ESR2) polymorphisms and endometrial cancer (United States) [J].Cancer Causes Control, 2004, 15 (6) :627-633.
    [25]LETONJA M, STEBLOVNIK K, PETERLIN B, et al.Oestrogen receptor dinucleotide (TA) polymorphism affects total and LDL cholesterol but does not predict premature myocardial infarction in Caucasian men[J].Acta Cardiol, 2005, 60 (3) :307-309.
    [26]ZHAI Y, ZHOU G, DENG G, et al.Estrogen receptor alpha polymorphisms associated with susceptibility to hepatocellular carcinoma in hepatitis B virus carriers[J].Gastroenterology, 2006, 130 (7) :2001-2009.
    [27]ZHANG W.The correlation between gene polymorphismss of ER gene and primary liver cancer[D].Chongqing:Chongqing Med Univ, 2008. (in Chinese) 张伟.雌激素受体基因多态性与原发性肝癌的关系研究[D].重庆:重庆医科大学, 2008.
    [28]LIU Y.Association between genetic polymorphism of estrogen receptor and susceptibility to type B hepatitis, cirrhosis, hepatocellular carcinoma[D].Nanning:Guangxi Med Univ, 2012. (in Chinese) 刘岩.雌激素受体基因多态性与乙型肝炎、肝硬化、肝癌的遗传易感性研究[D].南宁:广西医科大学, 2012.
    [29]YUAN XY.Genetic association study between candidate genes polymorphisms and hepatocellular carcinoma in Chinese population and function study of SNPs in the promoter of CD82[D].Chongqing:Third Milit Med Univ, 2007. (in Chinese) 苑晓燕.基于候选基因的肝癌遗传关联研究及CD82启动子区SNPs的功能研究[D].重庆:第三军医大学, 2007.
    [30]LOU JJ, XIE YA, LUO XL, et al.Study on the relationship between polymorphism of ESR1 gene and primary liver cancer[J].Chin J Oncol Prev Treat, 2009, 1 (2) :98-100. (in Chinese) 楼建军, 谢裕安, 罗小玲, 等.ESR1基因多态性与原发性肝癌发生的相关性研究[J].中国癌症防治杂志, 2009, 1 (2) :98-100.
    [31]YAN L, LUO XL, KUANG ZP, et al.Relationship between estrogen receptor-1 gene single nucleotide polymorphism and genetic susceptibility in 21 hepatocellular carcinoma families pedigrees of Zhuang population in Fusui County of Guangxi[J].Chin J Cancer Biother, 2014, 21 (5) :543-547. (in Chinese) 闫雷, 罗小玲, 匡志鹏, 等.广西扶绥县壮族人群ESR1基因SNP与肝癌家系遗传易感性的关系[J].中国肿瘤生物治疗杂志, 2014, 21 (5) :543-547.
    [32]ANGHEL A, NARITA D, SECLAMAN E, et al.Estrogen receptor alpha polymorphisms and the risk of malignancies[J].Pathol Oncol Res, 2010, 16 (4) :485-496.
    [33]LIU Y, LIU Y, HUANG X, et al.Association of Pvu II and Xba I polymorphisms in estrogen receptor alpha gene with the risk of hepatitis B virus infection in the Guangxi Zhuang population[J].Infect Genet Evol, 2014, 27:69-76.
    [34]ZHOU N, ZHANG YR, WEI SF, et al.Association of ERα-29gene polymorphisms with susceptibility to HBV-related hepatocellular carcinoma[J].J Clin Hepatol, 2015, 31 (2) :240-243. (in Chinese) 周宁, 张月荣, 魏世芳, 等.雌激素受体α-29位基因多态与HBV相关原发性肝癌易感性的关系[J].临床肝胆病杂志, 2015, 31 (2) :240-243.
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