中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 2
Feb.  2018
Turn off MathJax
Article Contents

Association between hepatitis C virus infection and atherosclerosis

DOI: 10.3969/j.issn.1001-5256.2018.02.042
  • Published Date: 2018-02-20
  • Chronic infection and inflammation are associated with the development of atherosclerosis, and hepatitis C virus (HCV) infection is a relatively common infectious disease.This article reviews the latest advances in the association between HCV infection and atherosclerotic diseases.Studies have shown that much evidence supports the fact that HCV infection can increase the incidence of coronary heart disease, stroke, and carotid atherosclerosis and the risk of death caused by cardiovascular events.HCV infection is a risk factor for atherosclerosis.Although the underlying mechanism needs further study, more attention should be paid to the prevention and control of atherosclerotic diseases among patients with hepatitis C.

     

  • loading
  • [1]Chinese Society of Hepatology and Chinese Society of Infectious Diseases, Chinese Medical Association.The guideline of prevention and treatment for hepatitis C:a 2015 update[J].J Clin Hepatol, 2015, 31 (12) :1961-1979. (in Chinese) 中华医学会肝病学分会, 中华医学会感染病学分会.丙型肝炎防治指南 (2015年更新版) [J].临床肝胆病杂志, 2015, 31 (12) :1961-1979.
    [2]YOUNOSSI Z, PARK H, HENRY L, et al.Extrahepatic manifestations of hepatitis C:a meta-analysis of prevalence, quality of life, and economic burden[J].Gastroenterology, 2016, 150 (7) :1599-1608.
    [3]SANDER D, WINBECK K, KLINGELHOFER J, et al.Reduced progression of early carotid atherosclerosis after antibiotic treatment and Chlamydia pneumoniae seropositivity[J].Circulation, 2002, 106 (19) :2428-2433.
    [4]ISHIZAKA N, ISHIZAKA Y, TAKAHASHI E, et al.Association between hepatitis C virus seropositivity, carotid-artery plaque, and intima-media thickening[J].Lancet, 2002, 359 (9301) :133-135.
    [5]DAI CY, CHUANG WL, HO CK, et al.Associations between hepatitis C viremia and low serum triglyceride and cholesterol levels:a community-based study[J].J Hepatol, 2008, 49 (1) :9-16.
    [6]LIN MS, GUO SE, CHEN MY, et al.The impact of hepatitis C infection on ischemic heart disease via ischemic electrocardiogram[J].Am J Med Sci, 2014, 347 (6) :478-484.
    [7]BUTT AA, XIAOQIANG W, BUDOFF M, et al.Hepatitis C virus infection and the risk of coronary disease[J].Clin Infect Dis, 2009, 49 (2) :225-232.
    [8]TSUI JI, WHOOLEY MA, MONTO A, et al.Association of hepatitis C virus seropositivity with inflammatory markers and heart failure in persons with coronary heart disease:data from the Heart and Soul study[J].J Card Fail, 2009, 15 (5) :451-456.
    [9]FORDE KA, HAYNES K, TROXEL AB, et al.Risk of myocardial infarction associated with chronic hepatitis C virus infection:a population-based cohort study[J].J Viral Hepat, 2012, 19 (4) :271-277.
    [10]AMBROSINO P, LUPOLI R, DI MINNO A, et al.The risk of coronary artery disease and cerebrovascular disease in patients with hepatitis C:a systematic review and meta-analysis[J].Int J Cardiol, 2016, 221:746-754.
    [11]LEE MH, YANG HI, WANG CH, et al.Hepatitis C virus infection and increased risk of cerebrovascular disease[J].Stroke, 2010, 41 (12) :2894-2900.
    [12]ADINOLFI LE, RESTIVO L, ZAMPINO R, et al.Chronic HCV infection is a risk of atherosclerosis.Role of HCV and HCV-related steatosis[J].Atherosclerosis, 2012, 221 (2) :496-502.
    [13]LIAO CC, SU TC, SUNG FC, et al.Does hepatitis C virus infection increase risk for stroke?A population-based cohort study[J].PLo S One, 2012, 7 (2) :e31527.
    [14]HSU CS, KAO JH, CHAO YC, et al.Interferon-based therapy reduces risk of stroke in chronic hepatitis C patients:a populationbased cohort study in Taiwan[J].Aliment Pharmacol Ther, 2013, 38 (4) :415-423.
    [15]BARAKAT AA, NASR FM, METWALY AA, et al.Atherosclerosis in chronic hepatitis C virus patients with and without liver cirrhosis[J].Egyptian Heart J, 2017, 69 (2) :139-147.
    [16]KIECHL S, EGGER G, MAYR M, et al.Chronic infections and the risk of carotid atherosclerosis:prospective results from a large population study[J].Circulation, 2001, 103 (8) :1064-1070.
    [17]MIYAJIMA I, KAWAGUCHI T, FUKAMI A, et al.Chronic HCV infection was associated with severe insulin resistance and mild atherosclerosis:a population-based study in an HCV hyperendemic area[J].J Gastroenterol, 2013, 48 (1) :93-100.
    [18]ASLAM F, ALAM M, LAKKIS NM.Hepatitis C and carotid atherosclerosis:a retrospective analysis[J].Atherosclerosis, 2010, 209 (2) :340-343.
    [19]OLUBAMWO OO, ONYEKA IN, MIETTOLA J, et al.Hepatitis C as a risk factor for carotid atherosclerosis-a systematic review[J].Clin Physiol Funct Imaging, 2016, 36 (4) :249-260.
    [20]PETTA S, TORRES D, FAZIO G, et al.Carotid atherosclerosis and chronic hepatitis C:a prospective study of risk associations[J].Hepatology, 2012, 55 (5) :1317-1323.
    [21]MOSTAFA A, MOHAMED MK, SAEED M, et al.Hepatitis C infection and clearance:impact on atherosclerosis and cardiometabolic risk factors[J].Gut, 2010, 59 (8) :1135-1140.
    [22]AMIN J, LAW MG, BARTLETT M, et al.Causes of death after diagnosis of hepatitis B or hepatitis C infection:a large community-based linkage study[J].Lancet, 2006, 368 (9539) :938-945.
    [23]GUILTINAN AM, KAIDAROVA Z, CUSTER B, et al.Increased allcause, liver, and cardiac mortality among hepatitis C virus-seropositive blood donors[J].Am J Epidemiol, 2008, 167 (6) :743-750.
    [24]VOLZKE H, SCHWAHN C, WOLFF B, et al.Hepatitis B and C virus infection and the risk of atherosclerosis in a general population[J].Atherosclerosis, 2004, 174 (1) :99-103.
    [25]PETTA S, MAIDA M, MACALUSO FS, et al.Hepatitis C virus infection is associated with increased cardiovascular mortality:a meta-analysis of observational studies[J].Gastroenterology, 2016, 150 (1) :145-155, e15-e16.
    [26]BODDI M, ABBATE R, CHELLINI B, et al.Hepatitis C virus RNA localization in human carotid plaques[J].J Clin Virol, 2010, 47 (1) :72-75.
    [27]FLETCHER NF, WILSON GK, MURRAY J, et al.Hepatitis C virus infects the endothelial cells of the blood-brain barrier[J].Gastroenterology, 2012, 142 (3) :634-643.
    [28]KANG RQ, CHEN HY.Relationship between fatty liver disease and carotid atherosclerosis in college teachers[J/CD].Chin J Liver Dis:Electronic Edition, 2016, 8 (1) :100-102. (in Chinese) 康荣芹, 陈红艳.高校教师脂肪肝与颈动脉粥样硬化相关性分析[J/CD].中国肝脏病杂志:电子版, 2016, 8 (1) :100-102.
    [29]LIU DJ, CHEN QF.Pathogenesis of insulin resistance and its impact on antiviral therapy in patients with chronic hepatitis C[J].J Clin Hepatol, 2017, 33 (6) :1152-1155. (in Chinese) 刘大吉, 陈青锋.慢性丙型肝炎患者胰岛素抵抗的发病机制及对抗病毒治疗的影响[J].临床肝胆病杂志, 2017, 33 (6) :1152-1155.
    [30]BANKS DE, BOGLER Y, BHUKET T, et al.Significant disparities in risks of diabetes mellitus and metabolic syndrome among chronic hepatitis C virus patients in the U.S[J].Diabetes Metab Syndr, 2016.[Epub ahead of print]
    [31]NAHON P, BOURCIER V, LAYESE R, et al.Eradication of hepatitis C virus infection in patients with cirrhosis reduces risk of liver and non-liver complications[J].Gastroenterology, 2017, 152 (1) :142-156.
    [32]van der MEER AJ, VELDT BJ, FELD JJ, et al.Association between sustained virological response and all-cause mortality among patients with chronic hepatitis C and advanced hepatic fibrosis[J].JAMA, 2012, 308 (24) :2584-2593.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (2190) PDF downloads(391) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return