中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 2
Feb.  2018
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Article Contents

Selection of direct-acting antiviral agents in treatment of chronic hepatitis C patients with renal dysfunction

DOI: 10.3969/j.issn.1001-5256.2018.02.007
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  • Published Date: 2018-02-20
  • The incidence of hepatitis C virus infection is commonly seen in patients with renal dysfunction (RD) , especially those with end-stage renal disease on hemodialysis (HD) , among whom the incidence and mortality of liver diseases increase.The development of direct-acting antiviral agents has revolutionized the therapy for chronic hepatitis C (CHC) with a sustained virologic response rate of > 90% and a low rate of adverse events.Grazoprevir/elbasvir, paritaprevir/ritonavir + ombitasvir + dasabuvir, glecaprevir/pibrentasvir, or daclatasvir + asunaprevir regimen is recommended in CHC patients with RD and HD, while the sofosbuvir-based regimen is not recommended.

     

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