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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 1
Jan.  2018
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Efficacy of Yunnan white medicinal powder combined with somatostatin and pantoprazole in treatment of liver cirrhosis complicated by upper gastrointestinal bleeding and its effect on inflammatory factors

DOI: 10.3969/j.issn.1001-5256.2018.01.019
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  • Published Date: 2018-01-20
  • Objective To investigate the efficacy of Yunnan white medicinal powder combined with somatostatin and pantoprazole in the treatment of liver cirrhosis complicated by upper gastrointestinal bleeding and its effect on inflammatory factors. Methods A total of 150 patients with liver cirrhosis complicated by upper gastrointestinal bleeding who were admitted to Shenyang 242 Hospital from April 2016 to March 2017 were enrolled and randomly divided into observation group and control group, with 75 patients in each group. The patients in the control group were given somatostatin for injection + pantoprazole sodium for injection, and those in the observation group were given Yunnan white medicinal powder in addition to the treatment for the control group. The two groups were observed and compared in terms of clinical outcome, blood transfusion volume, time to hemostasis, length of hospital stay, and change in hemoglobin, as well as the changes in the serum levels of high-sensitivity C-reactive protein ( hs-CRP) and interleukin-6 ( IL-6) after treatment. The t-test was used for comparison of continuous data between groups, the chi-square test was used for comparison of categorical data between groups, and the Ridit analysis and the u test were used for ranked data of clinical outcome. Results Compared with the control group, the observation group had a significantly lower blood transfusion volume and significantly shorter time to hemostasis and length of hospital stay ( t = 6. 357, 7. 360, and 4. 469, all P < 0. 01) , as well as a significantly higher level of hemoglobin after treatment ( t = 4. 042, P < 0. 01) . The observation group had a significantly higher overall response rate than the control group ( 96. 00% vs 85. 33% , u = 2. 564, P < 0. 05) . Both groups had significant reductions in the serum levels of hs-CRP and IL-6 after treatment ( t = 14. 240, 6. 943, 35. 277, and 17. 764, all P < 0. 01) , and the observation group had a significantly higher level of hs-CRP and IL-6 than the control group after treatment ( t = 7. 984 and 18. 946, both P < 0. 01) . Conclusion Yunnan white medicinal powder combined with somatostatin and pantoprazole has a marked clinical effect in the treatment of liver cirrhosis complicated by upper gastrointestinal bleeding and can reduce blood transfusion volume, shorten the time to hemostasis and length of hospital stay, and reduce the serum levels of hs-CRP and IL-6.

     

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