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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 12
Dec.  2017
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Article Contents

Effect of retrograde perfusion via the inferior vena cava on renal function in the early stage after liver transplantation

DOI: 10.3969/j.issn.1001-5256.2017.12.026
  • Received Date: 2017-06-19
  • Published Date: 2017-12-20
  • Objective To investigate the effect of retrograde perfusion via the inferior vena cava on renal function in the early stage after liver transplantation. Methods A retrospective analysis was performed for the clinical data of 103 patients with normal serum creatinine and blood urea nitrogen before surgery who underwent liver transplantation in Fuzhou General Hospital from January 2000 to December 2012. According to the surgical approach, these patients were divided into groups A ( orthotopic liver transplantation, 26 patients) and B ( retrograde perfusion via the inferior vena cava, 77 patients) . The two groups were compared in terms of preoperative data [age, sex, primary diseases ( liver cancer/liver cirrhosis) , Model for End-Stage Liver Disease ( MELD) score], time of inferior vena cava occlusion during surgery, intraoperative infusion volume and total volume of blood products, and urine volume, serum creatinine, and blood urea nitrogen at 1-7, 14, and 28 days after surgery. The independent samples t-test was used for comparison of continuous data between groups, and the chi-square test was used for comparison of categorical data between groups. Results Compared with group A, group B had a significantly shorter time of inferior vena cava occlusion and significantly lower intraoperative infusion volume and total volume of blood products ( t = 9. 945, 3. 127, and 5. 852, all P < 0. 05) . There was no significant difference in the incidence rate of acute renal failure after surgery between the two groups ( χ2= 1. 920, P > 0. 05) . At 1-2 days after surgery, group A had a significantly higher urine volume than group B ( t = 3. 613 and 2. 929, both P < 0. 05) ; at 2-7, 14, and 28 days after surgery, group B had significantly lower serum creatinine than group A ( t =2. 779, 2. 009, 2. 126, 2. 602, 1. 998, 2. 026, 2. 609, and 3. 870, all P < 0. 05) ; at 1-7, 14, and 28 days after surgery, group B had significantly lower blood urea nitrogen than group A ( t = 5. 895, 3. 212, 1. 830, 2. 348, 3. 030, 3. 549, 2. 287, 2. 996, and 2. 775, all P <0. 05) . Conclusion Retrograde perfusion via the inferior vena cava has little impact on renal function after surgery and brings benefits to the improvement and recovery of renal function after surgery.

     

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