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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 11
Nov.  2017
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Article Contents

New advances in the treatment of refractory primary biliary cholangitis

DOI: 10.3969/j.issn.1001-5256.2017.11.040
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  • Received Date: 2017-06-26
  • Published Date: 2017-11-20
  • Primary biliary cholangitis (PBC) is an autoimmune liver disease characterized by small bile duct injury.Ursodeoxycholic acid (UDCA) is often used for the treatment of this disease;however, about 40% of PBC patients do not respond adequately to UDCA and often have poor prognosis.This article summarizes the new therapeutic options for such patients.In 2017, obeticholic acid has been recommended as the second-line therapeutic drug for PBC patients with suboptimal response to UDCA by European Association for the Study of the Liver.Some achievements have been made in the research on fibrates and budesonide administered alone or in combination for the treatment of refractory PBC, but their efficacy and safety need to be further confirmed by large-sample, double-blind, randomized controlled trials.Monoclonal antibody, change in the production of bile acid, and drug reabsorption are still under experiment.At present, liver transplantation remains the only therapeutic method for patients with end-stage PBC.

     

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