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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 11
Nov.  2017
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Therapeutic strategies for patients with primary biliary cholangitis and suboptimal response to ursodeoxycholic acid

DOI: 10.3969/j.issn.1001-5256.2017.11.010
  • Received Date: 2017-09-03
  • Published Date: 2017-11-20
  • In recent years, ursodeoxycholic acid is commonly used for the treatment of primary biliary cholangitis (PBC) ;however, the growing number of PBC patients and the occurrence of suboptimal response and treatment intolerance pose a great challenge to treatment regimens.The approval of the new drug obeticholic acid brings hope to PBC patients, and a combination of fibrates also has a promising future.More studies are in progress.Although new drugs, such as monoclonal antibody, fibroblast growth factor 19, and sodium-dependent bile acid transporter inhibitor, have limited efficacy data, they provide new directions for the treatment of PBC.With the help of individualized follow-up and stratified therapy, the management of PBC patients will enter a new stage.

     

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