中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 10
Oct.  2017
Turn off MathJax
Article Contents

Advances in treatment of muscle cramp in liver cirrhosis

DOI: 10.3969/j.issn.1001-5256.2017.10.033
  • Received Date: 2017-04-06
  • Published Date: 2017-10-20
  • Muscle cramp is one of the common symptoms of patients with liver cirrhosis and significantly affects patients' quality of life. In general, the research on liver cirrhosis mainly focuses on the management and prevention of causes or common complications, and there are relatively few studies on the treatment of muscle cramp. Therefore, it is very important to find safe and effective therapeutic regimens. This article describes the pathogenesis and manifestations of muscle cramp in patients with liver cirrhosis, summarizes the therapeutic regimens with clinical value, including new drugs such as baclofen, L-carnitine, and taurine, and further elaborates on the protective effect of taurine against liver fibrosis via its activation of extracellular matrix and hepatic stellate cells, in order to provide new evidence for the treatment of muscle cramp in liver cirrhosis.

     

  • loading
  • [1]MILLER TM, LAYZER RB.Muscle cramps[J].Muscle Nerve, 2005, 32 (4) :431-442.
    [2]CHATRATH H, LIANGPUNSAKUL S, GHABRIL M, et al.Prevalence and morbidity associated with muscle cramps in patients with cirrhosis[J].Am J Med, 2012, 125 (10) :1019-1025.
    [3]MEHTA SS, FALLON MB.Muscle cramps in liver disease[J].Clin Gastroenterol Hepatol, 2013, 11 (11) :1385-1391.
    [4]BASKOL M, OZBAKIR O, CO爦KUN R, et al.The role of serum zinc and other factors on the prevalence of muscle cramps in nonalcoholic cirrhotic patients[J].J Clin Gastroenterol, 2004, 38 (6) :524-529.
    [5]ANGELI P, ALBINO G, CARRARO P, et al.Cirrhosis and muscle cramps:evidence of a causal relationship[J].Hepatology, 1996, 23 (2) :264-273.
    [6]HENRY ZH, NORTHUP PG.Baclofen for the treatment of muscle cramps in patients with cirrhosis:a new alternative[J].Hepatology, 2016, 64 (2) :695-696.
    [7]ELFERT AA, ABO ALI L, SOLIMAN S, et al.Randomized placebo-controlled study of baclofen in the treatment of muscle cramps in patients with liver cirrhosis[J].Eur J Gastroenterol Hepatol, 2016, 28 (11) :1280-1284.
    [8]NAKANISHI H, KUROSAKI M, TSUCHIYA K, et al.L-carnitine reduces muscle cramps in patients with cirrhosis[J].Clin Gastroenterol Hepatol, 2015, 13 (8) :1540-1543.
    [9]MEHTA SS, FALLON MB.Muscle cramps in cirrhosis:a moving target[J].Clin Gastroenterol Hepatol, 2015, 13 (8) :1544-1546.
    [10]LIU L, ZHANG DM, WANG MX, et al.The adverse effects of long-term l-carnitine supplementation on liver and kidney function in rats[J].Hum Exp Toxicol, 2015, 34 (11) :1148-1161.
    [11]ATLURI DK, VELURU C, MULLEN K.An alternative treatment for muscle cramps in patients with liver cirrhosis[J].Liver Int, 2013, 33 (3) :496-497.
    [12]MATSUZAKI Y, TANAKA N, OSUGA T.Is taurine effective for treatment of painful muscle cramps in liver cirrhosis?[J].Am JGastroenterol, 1993, 88 (9) :1466-1467.
    [13]YAMAMOTO S.Plasma taurine in liver cirrhosis with painful muscle cramps[J].Adv Exp Med Biol, 1996, 403:597-600.
    [14]MIYAZAKI T, MATSUZAKI Y, IKEGAMI T, et al.The harmful effect of exercise on reducing taurine concentration in the tissues of rats treated with CCl4administration[J].J Gastroenterol, 2004, 39 (6) :557-562.
    [15]de LUCA A, PIERNO S, CAMERINO DC.Taurine:the appeal of a safe amino acid for skeletal muscle disorders[J].J Transl Med, 2015, 13:243.
    [16]VIDOT H, CAREY S, ALLMAN-FARINELLI M, et al.Systematic review:the treatment of muscle cramps in patients with cirrhosis[J].Aliment Pharmacol Ther, 2014, 40 (3) :221-232.
    [17]MIYAZAKI T, KARUBE M, MATSUZAKI Y, et al.Taurine inhibits oxidative damage and prevents fibrosis in carbon tetrachlorideinduced hepatic fibrosis[J].J Hepatol, 2005, 43 (1) :117-125.
    [18]DEVI SL, VISWANATHAN P, ANURADHA CV.Regression of liver fibrosis by taurine in rats fed alcohol:effects on collagen accumulation, selected cytokines and stellate cell activation[J].Eur JPharmacol, 2010, 647 (1-3) :161-170.
    [19]GENTILE CL, NIVALA AM, GONZALES JC, et al.Experimental evidence for therapeutic potential of taurine in the treatment of nonalcoholic fatty liver disease[J].Am J Physiol Regul Integr Comp Physiol, 2011, 301 (6) :r1710-r1722.
    [20]MIYAZAKI T, BOUSCAREL B, IKEGAMI T, et al.The protective effect of taurine against hepatic damage in a model of liver disease and hepatic stellate cells[J].Adv Exp Med Biol, 2009, 643:293-303.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (1489) PDF downloads(372) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return