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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 5
May  2017
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Article Contents

Significance of serological markers in diagnosis of nonalcoholic fatty liver disease

DOI: 10.3969/j.issn.1001-5256.2017.05.037
  • Received Date: 2016-11-24
  • Published Date: 2017-05-20
  • In recent years, the incidence rate of fatty liver tends to increase markedly, and liver biopsy is the gold standard for the diagnosis of fatty liver, but it has some inevitable shortcomings.At present, there lacks a convenient, cheap, and accurate noninvasive diagnostic method for clinical practice.This article reviews the significance of various serological markers in the diagnosis of nonalcoholic fatty liver disease (NAFLD) and points out that liver enzyme, aspartate aminotransferase/alanine aminotransferase ratio, serum ferritin, serum selenium, uric acid, high fasting insulin level, retinol-binding protein-4, cytokeratin-18, PNPLA3 gene, and TM6SF2 gene have great significance in the diagnosis of NAFLD.There are still controversies over the value of interleukin-28 B in the diagnosis of NAFLD, and more clinical trials are needed.We believe that in the near future, a combination of various serum markers may become an accurate noninvasive method for the diagnosis of NAFLD and the assessment of the degree of liver fatty degeneration and fibrosis.

     

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