A systematic analysis of the application of diagnostic criteria for drug-induced liver injury in China based on the literature

Zhang Dong; Zhang Tao; Wu YuNan; Sun KeWei

doi:10.3969/j.issn.1001-5256.2017.05.026

Issue 5

May 2017

Turn off MathJax

Article Contents

Article Navigation > Journal of Clinical Hepatology > 2017 > 33(5): 919-923

PDF( 1605 KB)

A systematic analysis of the application of diagnostic criteria for drug-induced liver injury in China based on the literature

DOI: 10.3969/j.issn.1001-5256.2017.05.026

Graduate School, Hunan University of Chinese Medicine

Research funding:

Published Date: 2017-05-20

Abstract

Abstract

Objective To investigate the application of diagnostic criteria for drug-induced liver injury in China.Methods CNKI, VIP, and Wanfang Data were searched for articles published from 1990 to 2015, and the diagnostic criteria in the articles were recorded to investigate the current application of diagnostic criteria for drug-induced liver injury.Results A total of 609 articles were included, with 410 articles of case studies and 199 case reports.A total of 15 types of diagnostic criteria were used in China, and only 13.4% of these articles used the causality assessment method recommended by the international community.In 46% of the cases reported in the articles, a diagnosis was made based on clinical symptoms and exclusion of common causes of liver injury.Conclusion There are many diagnostic criteria for drug-induced liver injury in China, and the diagnosis is subjective and lacks rigor.
- drug induced liver injury,
- diagnosis,
- reference standards

FullText(HTML)

References(35)

References

[1]Drug induced Liver Disease Study Group, Chinese Society of Hepatology, Chinese Medicial Association.Guidelines for the management of durg-induced liver injury[J].J Clin Hepatol, 2015, 31 (11) :1752-1769. (in Chinese) 中华医学会肝病学分会药物性肝病学组.药物性肝损伤诊治指南[J].临床肝胆病杂志, 2015, 31 (11) :1752-1769.

[2]MICHAEL D, JOHN J, JAYANT A, et al.Drug-induced liver injury[J].Mayo Clin Proc, 2014, 89 (1) :95-106.

[3]GABY D, ROLF T.RUCAM in drug and herb induced liver injury:the update[J].Int J Mol Sci, 2016, 17 (14) :5-33.

[4]JONATHAN GS, JAMES HL.Drug-induced liver injury:a summary of recent advances[J].Expert Opin Drug Me, 2011, 7 (7) :875-890.

[5]DANAN G.Causality assessment of drug-induced liver injury:hepatology working group[J].J Hepatol, 1988, 7 (1) :132-136.

[6] DANAN G, BENICHHON C.Causality assessment of adverse re-actions to drugs-I.A novel method based on the conclusions of international consensus meetings:application to drug-induced liver injury[J].J Clin Epidemiol, 1993, 46 (11) :1323-1330.

[7]MARIA VA, VICTORINO RM.Development and validation of a clinical scale for the diagnosis of drug induced hepatitis[J].Hepatology, 1997, 26 (3) :664-669.

[8]HOOFNAGLE JH.Drug-induced liver injury network (DILIN) [J].Hepatology, 2004, 40 (4) :773.

[9] YE WF.Clinical hepatology[M].Tianjing:Tianjin Science and Technology Publishing House, 2002:723-724. (in Chinese) 叶维法.临床肝胆病学[M].天津:天津科学技术出版社, 2002:723-724.

[10]YAO GB.Drug-induced liver disease[J].Chin J Dig, 1999, 19 (5) :339-342. (in Chinese) 姚光弼.药物性肝病[J].中华消化杂志, 1999, 19 (5) :339-342.

[11]Cooperative Group for Hepatic and Gall Diseases, Chinese Society of Gastroenterology, Chinese Medical Association.Recommendations for the diagnosis and treatment of acute drug-induced liver injury (draft) [J].Chin J Dig, 2007, 27 (11) :765-767. (in Chinese) 中华医学会消化病学分会肝胆疾病协作组.急性药物性肝损伤诊治建议 (草案) [J].中华消化杂志, 2007, 27 (11) :765-767.

[12]ZHOU SM, JIA J.Clinical investiation and analysis of drug-induced liver disease in 494 cases[J].Chin Clin Med J, 2004, 11 (4) :494-495. (in Chinese) 周世明, 贾杰.494例药物性肝病的临床调查与分析[J].中国临床医学, 2004, 11 (4) :494-495.

[13]LI W, LIU CH.Acute drug-induced liver injury:a clinical analysis of 42 cases[J].China Prac Med, 2007, 2 (2) :52-55. (in Chinese) 李玮, 刘春华.急性药物性肝损害42例临床分析[J].中国实用医药, 2007, 2 (2) :52-55.

[14]JIAO L.Liver damage induced by Diao liu pills[J].ADRJ, 2010, 12 (4) :296-297. (in Chinese) 焦琳.凋瘤丸致药物性肝损害[J].药物不良反应杂志, 2010, 12 (4) :296-297.

[15]ZHANG WF.A case of liver damage caused by Fufang Qingdai capsules[J].Chin J Inf Tradit Chin Med, 2002, 9 (2) :59. (in Chinese) 张文芳.复方青黛胶囊引起肝损害1例[J].中国中医药信息杂志, 2002, 9 (2) :59.

[16]WANG L, WANG Z, ZHAN SY.Application of diagnostic criteria for drug-induced liver injury in articles published from 2005 to2012 in China[J].China J Chin Mater Med, 2013, 38 (3) :435-439. (in Chinese) 王蕾, 王忠, 詹思延.我国2005-2012年发表文献中药源性肝损伤诊断标准使用分析[J].中国中药杂志, 2013, 38 (3) :435-439.

[17]WANG XQ, HUANG HJ, CHEN XP, et al.Drug-induced liver injury:a clinical analysis of 67 cases[J].J Inter Intens Med, 2008, 14 (3) :156-157. (in Chinese) 王雪芹, 黄焕军, 陈兴平, 等.67例药物性肝损害的临床分析[J].内科急危重症杂志, 2008, 14 (3) :156-157.

[18]GUO QY.Drug-induced liver injury:a clinical analysis of 198 cases[J].Northwest Pharm J, 2003, 18 (3) :128-129. (in Chinese) 郭庆英.药物性肝损害198例分析[J].西北药学杂志, 2003, 18 (3) :128-129.

[19]ZHANG ZY, FENG CW, YIN YY.Drug-induced hepatitis:a clinical analysis of 68 cases[J].China Prac Med, 2013, 8 (35) :134-136. (in Chinese) 张振洋, 冯常炜, 殷言言.药物性肝炎68例临床分析[J].中国实用医药, 2013, 8 (35) :134-136.

[20]QI YB, QIU L, JIANG HL, et al.Clinical characteristics of druginduced liver injury:an analysis of 394 cases[J].J Clin Hepatol, 2014, 30 (5) :438-441. (in Chinese) 祁亚宾, 邱玲, 姜红丽, 等.药物性肝损伤394例临床特点分析[J].临床肝胆病杂志, 2014, 30 (5) :438-441.

[21]SHAO CP, WU CH, LI J, et al.Clinical features of drug-induced liver injury:an analysis of 122 cases[J].Chin Hepatol, 2012, 17 (9) :640-643. (in Chinese) 邵翠萍, 吴赤红, 李俊, 等.122例药物性肝损伤临床特点分析[J].肝脏, 2012, 17 (9) :640-643.

[22]WEI A, SHI XF.Clinical anaylysis of 344 cases of drug-induced hepatitis[J].J Mod Med Health, 2010, 26 (23) :3528-3530. (in Chinese) 魏傲, 石小枫.药物性肝炎344例临床分析[J].现代医药卫生, 2010, 26 (23) :3528-3530.

[23]KAPLOVITZ N.Drug-induced liver disorders implications for drug development and regulation[J].Drug Saf, 2001, 24 (7) :489-490.

[24]WANG QQ, HU XN, BAO ZJ.Progress in the diagnosis of druginduced liver injury[J].J Prac Hepatol, 2014, 17 (4) :441-444. (in Chinese) 王青青, 胡晓娜, 保志军.药物性肝损伤诊断进展[J].实用肝脏病杂志, 2014, 17 (4) :441-444.

[25]LUCENA MI, CAMARGO R, ANDRADE RJ, et al.Comparison of two clinical scales for causality assessment in hepatotoxicity[J].Hepatology, 2001, 33 (1) :123-130.

[26]SUN SS, FU QC, YANG J, et al.The efficacy of drug lymphocyte stimulation tese in diagnosis of drug-induced liver injury[J].Chin Hepatol, 2015, 20 (3) :215-217. (in Chinese) 孙双双, 傅青春, 杨俊, 等.药物淋巴细胞刺激试验在药物性肝损伤诊断中的意义[J].肝脏, 2015, 20 (3) :215-217.

[27]ROCKEY DC, SEEFF LB, ROCHON J, et al.Causality assessment in drug-induced liver injury using a structured expert opinion process:comparison to the roussel-uclaf causality assessment method[J].Hepatology, 2010, 51 (6) :2117-2126.

[28]YANG BH, ZHANG YT, ZHANG CY.Drug inuced liver injury[J].J Clin Exp Med, 2003, 2 (1) :62-64. (in Chinese) 杨冰华, 张轶停, 张春艳.药物性肝损害[J].临床和实验医学杂志, 2003, 2 (1) :62-64.

[29]ROLF T, ALBRECHT W, CHRISTIAN F, et al.Drug and herb induced liver injury:council for international organizations of medical sciences scale for causality assessment[J].World J Hepatol, 2014, 6 (1) :17-32.

[30]ARIE R, LEONARD B, MICHAEL M, et al.Causality assessment for suspected DILI during clinical phases of drug development[J].Drug Saf, 2014, 37 (1) :47-56.

[31]ROCHON J, PROTIVE P, SEEF LB, et al.Reliability of the roussel uclaf causality assessment method for assessing causality in drug-induced liver injury[J].Hepatology, 2008, 48 (4) :1175-1183.

[32]GARCTA M, STEPHENS C, LUCENA ML, et al.Causality assessment methods in drug induced liver injury:strengths and weaknesses[J].J Hepatol, 2011, 55 (3) :683-691.

[33]WANG JB, XIAO XH, DU XX, et al.Objective identification and early diagnosis of herb-induced liver injury based on translational toxicology[J].China J Chin Mater Med, 2014, 39 (1) :5-9. (in Chinese) 王伽伯, 肖小河, 杜晓曦, 等.基于转化毒理学的中药肝损害客观辨识与早期诊断[J].中国中药杂志, 2014, 39 (1) :5-9.

[34]TESCHKE R, SCHULZE J, SCHWARZENBOECK A, et al.Herbal hepatotoxicity:suspected cases assessed for alternative causes[J].Eur J Gastroenterol Hepatol, 2013, 25 (9) :1093-1098.

[35]Branch of Hepatobiliary, China Association of Chinese Medicine, Branch of Chinese Patent Medicine, China Association of Chinese Medicine.Guidelines for the clinical management of herb-induced liver injury[J].J Clin Hepatol, 2016, 32 (5) :835-843. (in Chinese) 中华中医药学会肝胆病分会, 中华中医药学会中成药分会.中草药相关肝损伤临床诊疗指南[J].临床肝胆病杂志, 2016, 32 (5) :835-843.

Relative Articles

Supplements(0)

Cited By

Proportional views

Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Get Citation

PDF

XML

Article Metrics

Article views (2724) PDF downloads(547)

A systematic analysis of the application of diagnostic criteria for drug-induced liver injury in China based on the literature

DOI: 10.3969/j.issn.1001-5256.2017.05.026

Abstract

References

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

A systematic analysis of the application of diagnostic criteria for drug-induced liver injury in China based on the literature

DOI: 10.3969/j.issn.1001-5256.2017.05.026

Abstract

References

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

About Journal

Submission Guideline

Journal Online

Hepatobiliary College

Guidelines

Export File

Citation

Format

Content