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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 5
May  2017
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Article Contents

Correlation between mRNA expression of heat shock protein in tumor tissue and tumor stage in patients with HBV-related hepatocellular carcinoma

DOI: 10.3969/j.issn.1001-5256.2017.05.015
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  • Published Date: 2017-05-20
  • Objective To investigate the correlation between mRNA expression of heat shock protein (HSP) and tumor stage in patients with HBV-related hepatocellular carcinoma (HCC) .Methods The GSE14520 data set was downloaded from gene expression omnibus in the website of the National Center of Biotechnology Information.A total of 25 HSP genes were obtained from the GSE14520 data, and after the comparison with the clinical data downloaded from the database, 220 HCC patients with mRNA expression of HSP and corresponding clinical data were enrolled.The mRNA expression of HSP in tumor tissues was measured, the TNM stage and Barcelona Clinic Liver Cancer (BCLC) stage were determined for each patient, and a correlation analysis was performed.The Kruskal-Wallis H non-parametric test was used for comparison between multiple groups, and univariate and multivariate logistic regression analyses were used to investigate the correlation between HSP and HCC tumor stage.Results With the increase in TNM stage, the expression of HSPA12 A, HSPA5, HSP90AA1, and HSPA13 gradually increased (all P<0.05) , while the expression of HSP90AA1 gradually increased with the increase in BCLC stage (P<0.05) .HSPA4L (OR=1.019, P=0.005) , HSPA12A (OR=1.077, P=0.026) , and HSP90AA1 (OR=1.001, P=0.002) were risk factors for TNM stage.HSPA9 was negatively correlated with TNM stage (OR=0.995, P=0.011) .HSPH1 (OR=1.005, P=0.041) , HSPA1B (OR=1.002, P=0.048) , and HSPA5 (OR=1.000, P=0.001) were risk factors for BCLC stage, and HSPA9 was negatively correlated with BCLC stage (OR=0.995, P=0.005) .Conclusion There is a certain correlation between HSPs and tumor stage in HCC patients.

     

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