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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 11
Nov.  2016
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Article Contents

Influence of interaction between endogenous miRNAs and hepatitis B virus in hepatocytes on hepatitis B virus transcription and related mechanisms

DOI: 10.3969/j.issn.1001-5256.2016.11.042
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  • Published Date: 2016-11-20
  • MicroRNAs( miRNAs) may be involved in the regulation of gene expression after transcription and play important roles in regulating hepatitis B virus( HBV) transcription and replication. This article summarizes the miRNAs with an anti- HBV effect in hepatocytes and4 regulatory mechanisms,as well as the mechanisms through which HBV affects the expression of endogenous miRNAs in hepatocytes via HBx and self- coding miRNAs and promotes replication. The analyses show that the interaction between endogenous miRNAs and HBV in hepatocytes forms a complex regulatory network,competes for the results of regulation,and determines the activity of HBV transcription and the trend of disease progression. In- depth studies on the mechanisms of the influence of interaction between endogenous miRNA and HBV in hepatocytes on HBV transcription have great significance in exploring new anti- HBV methods.

     

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