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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 9
Sep.  2016
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Research advances in diagnosis and treatment of IgG4-associated autoimmune hepatitis

DOI: 10.3969/j.issn.1001-5256.2016.09.042
  • Published Date: 2016-09-20
  • Autoimmune hepatitis( AIH) is a chronic progressive inflammatory disease involving the liver parenchyma. In recent years,there have been more studies focusing on IgG4- associated diseases. Foreign scholars have found that patients with AIH also have IgG4- positive plasma cell infiltration in the liver,suggesting that IgG4 may be involved in the pathogenesis of AIH,and this disease is considered a special type of AIH and thus it is called IgG4- associated AIH( IgG4- AIH). This article reviews the research advances in the diagnosis and treatment of AIH and IgG4- AIH,so as to enhance clinical doctors' knowledge of such diseases.

     

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  • [1]ZACHOU K,RIGOPOULOU E,DALEKOS GN.Autoantibodies and autoantigens in autoimmune hepatitis:important tools in clinical practice and to study pathogenesis of the disease[J].J Autoimmune Dis,2004,1(1):2.
    [2]UMEHARA H,OKAZAKI K,MASAKI Y,et al.A novel clinical entity,Ig G4-related disease(Ig G4RD):general concept and details[J].Mod Rheumatol,2012,22(1):1-14.
    [3]OKAZAKI K,UCHIDA K,MIYOSHI H,et al.Recent concepts of autoimmune pancreatitis and Ig G4-related disease[J].Clin Rev Allergy Immunol,2011,41(2):126-138.
    [4]UMEMURA T,ZEN Y,HAMANO H,et al.Clinical significance of immunoglobulin G4-associated autoimmune hepatitis[J].J Gastroenterol,2011,46(Suppl 1):48-55.
    [5]CHUNG H,WATANABE T,KUDO M,et al.Identification and characterization of Ig G4-associated autoimmune hepatitis[J].Liver Int,2010,30(2):222-231.
    [6]ISHIZU Y,ISHIGAMI M,KUZUYA T,et al.Immunoglobulin G4-associated autoimmune hepatitis later complicated by autoimmune pancreatitis:a case report[J].Hepatol Res,2016,46(6):601-606.
    [7]LI XM,MA X,QIU DK.Clinical analysis of 164 patients with autoimmune hepatic diseases[J].Chin J Gastroenterol Hepatol,2006,15(3):274-276,280.(in Chinese)李新民,马雄,邱德凯.164例自身免疫性肝病临床分析[J].胃肠病学和肝病学杂志,2006,15(3):274-276,280.
    [8]KRAWITT EL.Autoimmune hepatitis[J].N Engl J Med,2006,354(1):54-66.
    [9]ALVAREZ F,BERG PA,BIANCHI FB,et al.International Autoimmune Hepatitis Group Report:review of criteria for diagnosis of autoimmune hepatitis[J].J Hepatol,1999,31(5):929-938.
    [10]HENNES EM,ZENIYA M,CZAJA AJ,et al.Simplified criteria for the diagnosis of autoimmune hepatitis[J].Hepatology,2008,48(1):169-176.
    [11]HENEGHAN MA,AL-CHALABI T,Mc FARLANE IG.Cost-effectiveness of pharmacotherapy for autoimmune hepatitis[J].Expert Opin Pharmacother,2006,7(2):145-156.
    [12]OHIRA H,TAKAHASHI A.Current trends in the diagnosis and treatment of autoimmune hepatitis in Japan[J].Hepatol Res,2012,42(2):131-138.
    [13]MIYAKE Y,IWASAKI Y,KOBASHI H,et al.Efficacy of ursodeoxycholic acid for Japanese patients with autoimmune hepatitis[J].Hepatol Int,2009,3(4):556-562.
    [14]CZAJA AJ,BIANCHI FB,CARPENTER HA,et al.Treatment challenges and investigational opportunities in autoimmune hepatitis[J].Hepatology,2005,41(1):207-215.
    [15]MANNS MP,VOGEL A.Autoimmune hepatitis,from mechanisms to therapy[J].Hepatology,2006,43(2 Suppl 1):s132-s141.
    [16]KAMISAWA T,OKAMOTO A.Autoimmune pancreatitis:proposal of Ig G4-related sclerosing disease[J].J Gastroenterol,2006,41(7):613-625.
    [17]ISHAK KG.Pathologic features of chronic hepatitis.A review and update[J].Am J Clin Pathol,2000,113(1):40-55.
    [18]LIBERAL R,VERGANI D,MIELI-VERGANI G.Update on autoimmune hepatitis[J].J Clin Transl Hepatol,2015,3(1):42-52.
    [19]AMARAPUKAR AD,AMARAPURKAR DN.Immunoglobulin Ig G4and autoimmune hepatitis[J].Trop Gastroenterol,2015,36(2):112-117.
    [20]PAIK WH,RYU JK,PARK JM,et al.Clinical and pathological differences between serum immunoglobulin G4-positive and-negative type 1 autoimmune pancreatitis[J].World J Gastroenterol,2013,19(25):4031-4038.
    [21]BRITO-ZERN P,KOSTOV B,BOSCH X,et al.Therapeutic approach to Ig G4-related disease:a systematic review[J].Medicine(Baltimore),2016,95(26):e4002.
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