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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 9
Sep.  2016
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Elemene combined with transcatheter arterial chemoembolization in treatment of primary liver cancer: a meta-analysis

DOI: 10.3969/j.issn.1001-5256.2016.09.023
  • Published Date: 2016-09-20
  • Objective To investigate the short- term efficacy,long- term efficacy,and adverse effects of elemene combined with transcatheter arterial chemoembolization( TACE) in the treatment of primary liver cancer( PLC). Methods Pub Med,EMBASE,Cochrane Library,Chinese Scientific Journal Full- Text Database,Wanfang Data,CBM,and VIP were searched by two reviewers using the same search strategy for clinical studies on elemene combined with TACE in the treatment of PLC. The Jadad quality scoring system was used to assess the quality of the studies included,and Review Manager 5. 2 software was used for the meta- analysis. Results A total of 9 articles involving487 patients were included. The results of the meta- analysis showed that compared with the TACE group,the elemene- TACE group showed significant increases in the response rate,disease control rate,and 12- and 24- month survival rates( response rate: RR = 1. 43,95% CI: 1. 23- 1. 67,P < 0. 001; disease control rate: RR = 1. 22,95% CI: 1. 11- 1. 32,P < 0. 001; 12- month survival rate: RR = 1. 68,95% CI: 1. 22- 2. 31,P = 0. 001; 24- month survival rate: RR = 2. 91,95% CI: 1. 44- 5. 87,P = 0. 003). As for the incidence of adverse events,the elemene- TACE group showed a significant reduction in the incidence rate of abdominal pain( RR = 0. 59,95% CI: 0. 36-0. 98,P = 0. 04). Conclusion Compared with TACE alone,elemene combined with TACE might improve response rate,disease control rate,and survival rates and reduce adverse events in patients with liver cancer.

     

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  • [1]QIU GQ,XU LZ,LIN ZC,et al.Clinical observation on interventional therapy of liver cancer with support of 320row CT[J].Chin JMed Offic,2014,42(2):133-139.(in Chinese)邱国钦,许丽贞,林智才,等.320排CT支持下肝癌介入治疗的临床观察[J].临床军医杂志,2014,42(2):133-139.
    [2]YU HP,GUO Z,YANG XL,et al.Progress research on transarterial radioembolization in treatment of hepatocellular carcinoma[J].J Jilin Univ:Med Edition,2016,42(3):626-629.(in Chinese)于海鹏,郭志,杨雪玲,等.经肝动脉放疗性栓塞治疗肝癌的研究进展[J].吉林大学学报:医学版,2016,42(3):626-629.
    [3]KUDO M,HAN G,FINN RS,et al.Brivanib as adjuvant therapy to transarterialchemoem-bolization in patients with hepatocellular carcinoma:a randomized phaseⅢtrial[J].Hepatology,2014,60(5):1697-1707.
    [4]ZHAO YJ.Clinical effect of chemoembolization combined with radiofrequency ablation in treatment of liver cancer:an analysis of 26 cases[J].Chin J Pract Intern Med,2015,35(s1):115-116.(in Chinese)赵延吉.化疗栓塞术联合射频消融治疗肝癌26例疗效分析[J].中国实用内科杂志,2015,35(s1):115-116.
    [5] XIE T,ZENG ZW,LI CL,et al.Industrialization and clinical application of innovative natural anticancer target drugs of King Kong elemene liposomes[C]//.Proceedings of the Annual Meeting of Editing and Publishing Branch of China Association of Chinese Medicine and Summit on Traditional Chinese Medicine and Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Liver Diseases and Liver Cancer in 2014.Suzhou,2014.(in Chinese)谢恬,曾昭武,李铖璐,等.原创药金港榄香烯脂质体系列靶向抗癌天然药物产业化及临床应用[C]//.2014年中华中医药学会编辑出版分会年会暨全国中医、中西医结合防治肝病、肝癌高峰论坛.苏州,2014.
    [6]LIU Y,CAO Y,SUI X,et al.Effects of elemene combined with hyperthermia on apotosis and P-Akt experssion in bladder cancer cell line BIOU-87[J].Chin J Med Offic,2014,42(1):31-34.(in Chinese)刘悦,曹阳,隋欣,等.榄香烯联合热疗诱导膀胱癌BIU-87细胞凋亡及对P-Akt表达的影响[J].临床军医杂志,2014,42(1):31-34.
    [7]GU HF,QU YH,WU CR,et al.An experimental study on the effects ofβ-elemene on tubulin polymerization and antitumor in Vitro[J].J Hunan Coll Tradit Chin Med,2005,25(3):16-18.(in Chinese)顾洪丰,瞿延晖,伍参荣,等.β-榄香烯抗肿瘤作用和抑制微管蛋白体外聚合的研究[J].湖南中医学院学报,2005,25(3):16-18.
    [8]LI CL,CHANG L,GUO L,et al.β-elemene induces caspase-dependent apoptosis in human glioma cell in vitro through the upregulation of Bax and Fas/FasL and downregulation of Bcl-2[J].Asian Pac JCancer Prev,2014,15(23):10407-10412.
    [9]LEI T,ZHOU L,ZHENG LY,et al.Elemene displays anti-cancer ability on laryngeal cancer cells in vitro and in vivo[J].Cancer Chemother Pharmacol,2006,58(1):24-34.
    [10]ZHANG H,XU F,XIE T,et al.β-elemene induces glioma cell apoptosis by downregulating survivin and its interaction with hepatitis B X-interacting protein[J].Oncol Rep,2012,28(6):2083-2090.
    [11]CHENG XX.β-elemene,by restraining Wnt signaling pathway,function as a dual role of anti-tumor and anti-inflammation in U251 and macrophage[D].Hangzhou normal university,2013.(in Chinese)成夏炫.β-榄香烯在U251和巨噬细胞中通过抑制Wnt信号通路发挥抗肿瘤和抑制炎症的双重作用[D].杭州师范大学,2013.
    [12]YAO YQ,XU YH,ZHOU HY,et al.Role of ERK in the inhibitory effects of elemene on the proliferation of rat C6 glioblastoma cells[J].Tumor,2007,27(10):777-786.(in Chinese)姚轶群,徐英辉,周洪语,等.ERK在榄香烯抑制大鼠C6胶质瘤细胞增殖中的作用[J].肿瘤,2007,27(10):777-786.
    [13]SHI H,LIU L,CHEN L,et al.Inhibition of tumor growth byβ-elemene through dow nregulation of the expression of u PAR,MMP-2,and MMP-9 in a murine intraocular melanoma modet[J].Melanoma Res,2015,25(1):15-21.
    [14]SHI H,LIU L,LIU L,et al.β-Elemene inhibits the metastasis of B16F10 melanoma cells by downregulation of the expression of u PA,u PAR,MMP-2,and MMP-9[J].Melanoma Res,2014,24(2):99-107.
    [15]CHEN W,LU Y,WU J,et al.Beta-elemene inhibits melanoma growth and metastasis via suppressing vascular endothelial growth factor-mediated angiogenesis[J].Cancer Chemother Pharmacol,2011,67(4):799-808.
    [16]JADAD AR,MOORE RA,CARROLL D,et al.Assessing the quality of reports of randomized clinical trials:is blinding necessary?[J].Control Clin Trials,1996,17(1):1-12.
    [17]ZHANG ZP.Hepatic interventional therapy with elemene emulsion as adjuvant therapy for primary liver cancer:an analysis of 22 cases[J].Acta Acad Med Bengbu,2001,26(4):341.(in Chinese)张震平.榄香烯乳肝动脉介入佐治原发性肝癌22例[J].蚌埠医学院学报,2001,26(4):341.
    [18]CHEN J,WANG F,YANG BH,et al.Elemene combined with interventional treatment for advanced liver cancer:an analysis of 92cases[J].J Intervent Radiol,2002,11(3):210-212.(in Chinese)陈骏,王峰,杨葆华,等.榄香烯联合介入治疗中晚期肝癌92例[J].介入放射学杂志,2002,11(3):210-212.
    [19]CHEN P,HUANG P,WU JB.Observation on the therapeutic effect of transcatheterarterial infusion chemotherapy combined with elemene emulsion for the treatment intermediate and late stage hepatic carcinoma[J].Acta Acad Med Jiangxi,2005,45(5):104-106.(in Chinese)陈平,黄平,吴建兵.榄香烯乳联合化疗药物肝动脉介入治疗中晚期肝癌[J].江西医学院学报,2005,45(5):104-106.
    [20]SONG J,XU H,TANG JQ,et al.Transcatheter hepatic arterial infusion chemotherapy combined with element emulsion for treatment of primary hepatic carcinoma[J].Chin Pharmaceuticals,2007,16(16):23-24.(in Chinese)宋杰,许虹,唐家强,等.肝动脉灌注榄香烯乳联合化疗药物治疗原发性肝癌临床研究[J].中国药业,2007,16(16):23-24.
    [21] YU CH,ZHANG KL.Clinical efficacy of elemene emulsion combined with transcatheter arterial chemoembolization for treatment of advanced liver cancer[J].World Health Dig Med Period,2009,6(23):96.(in Chinese)于春虎,张魁灵.榄香烯乳加TACE治疗晚期肝癌临床观察[J].中外健康文摘,2009,6(23):96.
    [22]XU XM,CHEN MC,CHEN DL,et al.Beta-elemene emulsion combined with transcatheter arterial chemoembolization in the treatment for 21 cases with advanced hepatocellular carcinoma[J].JChin Oncol,2011,17(5):363-365.(in Chinese)徐雪明,陈明聪,陈德连,等.β-榄香烯乳联合肝动脉化疗栓塞治疗中晚期肝癌21例[J].肿瘤学杂志,2011,17(5):363-365.
    [23]ZHAO C,ZHANG YC,ZHANG YY,et al.Clinical efficacy of elemene injection combined with interventional chemotherapy for primary liver cancer[J].Chin J Diffic and Compl Cas,2012,11(11):882-883.(in Chinese)赵成,张蕴超,孙一予,等.榄香烯注射液联合介入化疗治疗原发性肝癌的临床研究[J].疑难病杂志,2012,11(11):882-883.
    [24]ZHANG X,FANG WY.Clinical efficacy of elemene combined with transcatheter arterial chemoembolization in treatment of primary liver cancer[J].Shanxi J Tradit Chin Med,2015,31(5):23-24.(in Chinese)张信,方文岩.榄香烯联合TACE治疗原发性肝癌临床观察[J].山西中医,2015,31(5):23-24.
    [25]CHEN DL,JIANG HH.Short-term therapeutic effect of elemene combined with interventional therapy for moderate and advanced liver cancer[J].J Guangzhou Univ Tradit Chin Med,2015,33(1):27-30.(in Chinese)陈德连,江会红.榄香烯联合介入治疗中晚期肝癌患者的近期疗效[J].广州中医药大学学报,2015,33(1):27-30.
    [26]ZHU T,LI X,LUO L,et al.Reversion of malignant phenotypes of humanglioblasto-ma cells byβ-elemene throughβ-cateninmediated regulation of stemness-,differentiation-and epithelialto-mesenchymal transition-related molecules[J].J Transl Med,2015,13(1):356.
    [27]MAO Y,ZHANG J,HOU L,et al.The effect of beta-elemeneon alpha-tubulin polymerization in human hepatoma HepG 2 cells[J].Chin J Cancer Res,2013,25(6):770-776.
    [28]LIU JS,HE SC,ZHANG ZL,et al.Anticancer effects ofβ-elemeneingastric cancer cells and its potential underlying proteins:a proteomic study[J].Oncol Rep,2014,32(6):2635-2647.
    [29] SHI H,LIU L,LIU LM,et al.Inhibition of tumor growth byβ-elemene through downregulation of the expression of uP A,uP AR,MMP-2,and MMP-9 in a murine intraocular melanoma model[J].Melanoma Res,2015,25(1):15-21.
    [30]ZHAO S,WU J,ZHENG F,et al.β-elemene inhibited expression of DNA methyltra-nsferase 1 through activation of ERK1/2and AMPKαsignalling pathways in human lung cancercells:the role of Sp1[J].J Cell Mol Med,2015,19(3):630-641.
    [31]HU Z,WU H,LI Y,et al.β-Elemene inhibits the proliferation of esophageal squamous cell carcinoma by regulating long noncoding RNA-mediated inhibition of h TERT expression[J].Anticancer Drugs,2015,26(5):531-539.
    [32]ZHENG J,LIU Q,REN KX,et al.Migratory and invasiveability of hepatocellular carcinoma cell line SK-hep-1 effected byβ-elemene[J].J Mod Oncol,2009,17(11):2054-2058.(in Chinese)郑瑾,刘强,任凯夕,等.β-榄香烯对肝癌细胞SK-hep-1的迁移和侵袭力的影响[J].现代肿瘤医学,2009,17(11):2054-2058.
    [33]GUO X,QIN Y,TAN J,et al.Antitumor effects and possible mechanism of elemene on expression in ascites hepatoma cell line H22[J].Chin J Clin Parm,2013,22(3):155-159.(in Chinese)郭霞,秦岩,谭婧,等.榄香烯对肝癌H22细胞荷瘤小鼠的抑瘤作用及其可能机制[J].中国临床药学杂志,2013,22(3):155-159.
    [34]NI FF,LIU YJ,ZHOU H,et al.Treatment of hepatic cancer in mice by beta-elemene combined DC/Dribble vaccine:an immune mechanism research[J].Chin J Integr Tradit West Med,2013,33(2):214-219.(in Chinese)倪菲菲,刘亚军,周浩,等.β-榄香烯联合DC/DRibble疫苗治疗小鼠肝癌免疫机制研究[J].中国中西医结合杂志,2013,33(2):214-219.
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