中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 7
Jul.  2016
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Article Contents

Strategy for virologic response-guided therapy in integrated diagnosis and treatment of hepatitis C in the era of precision medicine in China

DOI: 10.3969/j.issn.1001-5256.2016.07.008
  • Received Date: 2016-05-03
  • Published Date: 2016-07-20
  • At present,long- acting interferon combined with ribavirin is still a major therapeutic method for hepatitis C in China,and precision medicine can help cure more patients with hepatitis C. This article briefly introduces the diagnosis and treatment of hepatitis in China and the importance of the strategy of virologic response- guided therapy( RGT),and analyzes the influencing factors for the achievement of sustained virologic response. HCV RNA quantitation is the foundation of RGT strategy,and HCV RNA quantitation with a high specificity performed at crucial time points during treatment helps to evaluate response accurately,realize the individualized treatment of hepatitis C,and improve the cure rate of hepatitis C.

     

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  • [1] COLLINS FS,VARMUS H.A new initiative on precision medicine[J].N Engl Med,2015,372(9):793-795.
    [2]JAMESON JL,LONGO DL.Precision medicine---personalized,problematic,and promising[J].N Engl Med,2015,372(23):2229-2234.
    [3]MOHD HANAFIAH K,GROEGER J,FLAXMAN AD,et al.Global epidemiology of hepatitis C virus infection:new estimates of age-specific antibody to HCV seroprevalence[J].Hepatology,2013,57(4):1333-1342.
    [4]MAJUMDAR A,KITSON MT,ROBERTS SK.Systematic review:current concepts and challenges for the direct-acting antiviral era in hepatitis C cirrhosis[J].Aliment Pharmacol Ther,2016,43(12):1276-1292.
    [5]GUTIERREZ JA,LAWITZ EJ,POORDAD F.Interferon-free,direct-acting antiviral therapy for chronic hepatitis C[J].Viral Hepat,2015,22(11):861-870.
    [6]RAO H,WEI L,LOPEZ-TALAVERA JC,et al.Distribution and clinical correlates of viral and host genotypes in Chinese patients with chronic hepatitis C virus infection[J].J Gastroenterol Hepatol,2014,29(3):545-553.
    [7]LEE MH,YANG HI,LU SN,et al.Chronic hepatitis C virus infection increases mortality from hepatic and extrahepatic diseases:a community-based long-term prospective study[J].J Infect Dis,2012,206(4):469-477.
    [8]LEE MH,YANG HI,LU SN,et al.Hepatitis C virus genotype 1b increases cumulative lifetime risk of hepatocellular carcinoma[J].Int J Cancer,2014,135(5):1119-1126.
    [9]WEI L.Present situation of hepatitis C virus antiviral therapy and application prospects of small molecule drugs in our country[J].Chin J Hepatol,2013,21(6):403-405.魏来.我国丙型肝炎抗病毒治疗现状与小分子药物的应用前景[J].中华肝脏病杂志,2013,21(6):403-405.
    [10]YU ML,DAI CY,HUANG JF,et al.Rapid virological response and treatment duration for chronic hepatitis C genotype 1 patients:a rondomized trial[J].Hepatology,2008,47(6):1884-1893.
    [11]HUANG CF,YANG JF,HUANG JF,et al.Early identification of achieving a sustained virological response in chronic hepatitis C patients without a rapid virological response[J].J Gastroenterol Hepatol,2010,25(4):758-765.
    [12]SWAIN MG,LAI MY,SHIFFMAN ML,et al.A sustained virologic response is durable in patients with chronic hepatitis C treated with peginterferon alfa-2a and ribavirin[J].Gastroenterology,2010,139(5):1593-1601.
    [13]Chinese Society of Hepatology and Chinese Society of Infectious Diseases,Chinese Medical Association.The guideline of prevention and treatment for hepatitis C:a 2015 update[J].J Clin Hepatol,2015,31(12):1961-1979.(in Chinese)中华医学会肝病学分会,中华医学会感染病学会分会.丙型肝炎防治指南(2015年更新版)[J].临床肝胆病杂志,2015,31(12):1961-1979.
    [14]OMATA M,KANDA T,WEI L,et al.APASL consensus statements and recommendation on treatment of hepatitis C[J].Hepatol Int,2016.[Epub ahead of print]
    [15]European Association for the Study of the Liver.EASL recommendations on treatment of hepatitis C 2015[J].J Hepatol,2015,63(1):199-236.
    [16]WANG J,JIN Q,RAO HY,et al.Comparison of domestic reagents and Roche COBAS Taq Man in rapid and early virological response in patients with chronic hepatitis C[J].Infect Dis Info,2012,25(3):177-179.(in Chinese)王剑,金茜,饶慧瑛,等.国产试剂与Roche COBAS Taq Man试剂对慢性丙型肝炎快速和早期病毒学应答的比较研究[J].传染病信息,2012,25(3):177-179.
    [17]WHO Guidelines Approved by the Guidelines Review Committee.Guidelines for the screening care and treatment of persons with chronic hepatitis C infection:updated version[EB/OL].http://www.who.int/publications/guidelines/en/
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