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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 5
May  2016
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Research advances in the role of autophagy in liver cells and regulation of MAPK pathway

DOI: 10.3969/j.issn.1001-5256.2016.05.048
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  • Published Date: 2016-05-20
  • Autophagy is a highly conservative cellular process in eukaryotes that plays an important role in nutrition and energy metabolism in the liver. It can promote the autophagy of hepatocytes and protect the hepatocytes against the adverse external stimulation,but excessive autophagy can cause autophagic cell death of hepatocytes. Hepatic stellate cells( HSC) play an important role in the development and progression of liver fibrosis. Autophagy can provide energy for their activation,but may also lead to their death. This article introduces the relationship of autophagy with hepatocytes / HSC and the mitogen- activated protein kinase pathway,and points out that in- depth studies on the relationship between autophagy and pathway regulation during liver fibrosis can provide new targets for developing antifibrotic drugs.

     

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