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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 5
May  2016
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Article Contents

Effect of endoscopic injection of cyanoacrylate in treatment of acute esophageal and gastric variceal bleeding in children

DOI: 10.3969/j.issn.1001-5256.2016.05.024
  • Received Date: 2015-11-30
  • Published Date: 2016-05-20
  • Objective To investigate the effect and safety of endoscopic injection of cyanoacrylate in the treatment of esophageal and gastric variceal bleeding( EGVB) in children. Methods The clinical data of 35 children with acute EGVB who were treated with endoscopic injection of cyanoacrylate in Children's Hospital of Baoji Maternal and Child Health Care Hospital from August 2010 to August 2015 were analyzed retrospectively. The emergency response rate,rebleeding rate,and incidence of complications after the treatment were analyzed statistically. Results Thirty- five patients received 46 times of endoscopic injection of cyanoacrylate in total. The response rate to the initial injection was 95. 6%( 44 /46). The volume of cyanoacrylate injected was 0. 2- 0. 6 ml,with a mean volume of 0. 4 ± 0. 2 ml. The emergency hemostasis rate was 93. 4%( 43 /46),the rebleeding rate was 11. 4%( 4 /35),and the cycle for 4 patients with the recurrence of bleeding to be cured was 1. 2- 23. 0 months( mean 12. 1 ± 10. 9 months). One patient experienced abdominal pain,and no patients experienced ectopic embolism. Two patients died after injection. Conclusion Frequent,small- volume endoscopic injection of cyanoacrylate is an effective and convenient therapeutic method for EGVB in children,has few complications,and holds promise for clinical application.

     

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  • [1]de FRANCHIS R.Revising consensus in portal hypertension:report of the Baveno V consensus workshop on methodology of diagnosis and therapy in portal hypertension[J].J Hepatol,2010,53(4):762-768.
    [2]RIVET C,ROBLES-MEDRANDA C,DUMORTIER J,et al.Endoscopic treatment of gastroesophageal varices in young infants with cyanoacrylate glue:a pilot study[J].Gastrointest Endosc,2009,69(9):1034-1038.
    [3]KIM SJ,KIM KM.Recent trends in the endoscopic management of variceal bleeding in children[J].Pediatr Gastroenterol Hepatol Nutr,2013,16(1):1-9.
    [4]YANG Y,FAN YH,FANG L,et al.Risk factors of early rebleeding after endoscopic treatment of gastroesophageal varices[J].J Clin Hepatol,2013,29(3):178-181.(in Chinese)杨艳,樊艳华,房龙,等.内镜治疗食管胃静脉曲张早期再出血的影响因素分析[J].临床肝胆病杂志,2013,29(3):178-181.
    [5]EL-RIFAI N,MENTION K,GUIMBER D,et al.Gastropathy and gastritis in children with portal hypertension[J].J Pediatr Gastroenterol Nutr,2007,45(1):137-140.
    [6]CAI JW,ZHOU YS.Endoscopic histoacryl injection combined with ligation in the treatment of severe esophageal and gastric varices[J].J Clin Rehabil Tissue Eng Res,2015,19(12):1894-1898.(in Chinese)蔡金伟,周应生.组织胶内镜注射联合套扎法治疗重度食管胃底静脉曲张[J].中国组织工程研究,2015,19(12):1894-1898.
    [7]GARCIA-TSAO G,SAN AL AJ,GRACE ND,et al.Prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis[J].Hepatology,2007,46(3):922-938.
    [8]LO GH,LIANG HL,CHEN WC,et al.A prospective,randomized controlled trial of transjugular intrahepatic portosystemic shunt versus cyanoacrylate injection in the prevention of gastric variceal rebleeding[J].Endoscopy,2007,39(8):679-685.
    [9]KIYOSUE H,IBUKURO K,MARUNO M,et al.Multidetector CT anatomy of drainage routes of gastric varices:apictorial review[J].Radiographics,2013,33(1):87-100.
    [10]MARQUES P,MALUF-FILHO F,KUMAR A,et al.Long-term outcomes of acute gastric variceal bleeding in 48 patients following treatment with cyanoacrylate[J].Dig Dis Sci,2008,53(2):544-550.
    [11]DUCHM,DUCOT B,TOURNAY E,et al.Prognostic value of endoscopy in children with biliary atresia at risk for early development of varices and bleeding[J].Gastroenterology,2010,139(6):1952-1960.
    [12]KIM SJ,OH SH,JO JM,et al.Experiences with endoscopic interventions for variceal bleeding in children with portal hypertension:a single center study[J].Pediatr Gastroenterol Hepatol Nutr,2013,16(4):248-253.
    [13]SOEHENDRA N,IZBICKI J,NEUHAUS P,et al.Long-term recurrence of neoplasia and Barrett's epithelium after complete endoscopic resection[J].Gut,2014,63(10):1535-1543.
    [14]SHNEIDER BL,BOSCH J,de FRANCHIS R,et al.Portal hypertension in children:expert pediatric opinion on the report of the Baveno V Consensus Workshop on methodology of diagnosis and therapy in portal hypertension[J].Pediatr Transplant,2012,16(5):426-437.
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