Thymosin β4 exists in most human tissues and cells,involved in many physiological and pathological processes in the human body,such as anti- inflammation,wound healing,angiogenesis,and tumor metastasis. In recent years,thymosin β4 has been found to play an important role in the development and progression of liver diseases. This article reviews the relationship between thymosin β4 and the development and progression of liver diseases,indicating that further exploration of thymosin β4 would make it a new biomarker in diagnosing and treating liver diseases.