Association between PI3K/Akt/mTOR/p70S6K signaling pathway and hepatic fibrosis

Phosphoinositide 3-kinase( PI3K) / protein kinase-B( Ak T) / mammalian target of rapamycin( m TOR) /70-k Da ribosomal protein S6 kinase( p70S6K),PI3K/Akt/m TOR/p70S6 K,is an important signaling pathway in the life activities of cells,and it plays an important role in promoting the growth,proliferation,invasion,and anti-apoptosis of cells and promoting angiogenesis. It was clarified that the PI3 K / Akt / m TOR / p70S6 Ksignaling pathway is involved in regulating the activities of hepatic stellate cell( HSC),thus influencing the development and progression of hepatic fibrosis. Analysis demonstrated that blocking any target of the PI3 K / Akt / m TOR / p70S6 Ksignaling pathway can inhibit the activation and proliferation of HSC,promote the apoptosis of HSC,inhibit the extracellular matrix secretion from HSC,and delay the progression of hepatic fibrosis. Blocking the pathway is expected to be a treatment strategy for hepatic fibrosis.