Objective To analyze the distribution characteristics of hepatitis C virus( HCV) genotypes in Xingtai,China,and their relationship with disease progression and sustained virologic response( SVR),and to provide a basis for the prognostic judgment. Methods A retrospective analysis was performed among 231 patients with hepatitis C who lived in Xingtai and were newly diagnosed and treated in our hospital from December 2010 to December 2014. In those patients,general information was collected,and alanine aminotransferase,aspartate aminotransferase,white blood cell,genotype,and viral load were determined. Continuous data were analyzed using analysis of variance,and categorical data were analyzed using χ2test. Results In all patients,patients with 1b subtype accounted for the highest proportion( n =109,47. 2%),followed by patients with 2a subtype( n = 89,38. 5%). There was significant difference in gender distribution between patients with different genotypes( χ2= 13. 461,P = 0. 009). There was significant difference in HCV RNA load between patients with different genotypes( F = 13. 461,P = 0. 034). Particularly,patients with type 1 HCV had a significantly higher viral load than patients with type2 or 3 HCV. There was also significant difference in severity of liver disease between patients with different genotypes( P < 0. 001). Particularly,the incidence rate of cirrhosis or liver cancer in patients with type 1b HCV was higher than that in patients with other genotypes. The incidence of SVR was significantly higher in patients with type 2 HCV than type 1 HCV( 93. 1% vs 69. 4 %,χ2= 19. 850,P < 0. 001).In all patients,112( 48. 5%) had a rapid virologic response( RVR),and there was significant difference in the incidence of SVR between patients with and without a RVR( 96. 4% vs 64. 7%,χ2= 36. 407,P < 0. 001). In all patients,169 had a complete early virologic response( c EVR),and there was significant difference in the incidence of SVR between patients with and without a c EVR( 88. 8%vs 56. 5%,χ2= 29. 684,P < 0. 001). Conclusion In patients with HCV in Xingtai,1b subtype accounts for the highest proportion,followed by 2a subtype. There are significant differences in sex,RNA viral load,SVR,and severity of liver disease between patients with different genotypes. An analysis of genotype before treatment is important for the treatment,disease progression,and prognosis of patients with HCV. RVR and cEVR well predict the incidence of SVR: patients with these virologic responses are likely to achieve a SVR.
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