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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 6
Jun.  2015
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Article Contents

Research progress in c-Met and hepatocellular carcinoma

DOI: 10.3969/j.issn.1001-5256.2015.06.038
  • Published Date: 2015-06-20
  • c- Met plays a pivotal role in the development and progression of hepatocellular carcinoma( HCC),which can lead to proliferation,survival,cytoskeleton reorganization,separation and diffusion,and angiogenesis of tumor cells. Moreover,c- Met is an important prognostic factor for HCC. In HCC,c- Met acts as an activator of a series of signaling pathways,including PI3 K / AKT / m TOR,ERK /MAPK,and Rac- Pak. In recent years,it has been reported that small- molecule kinase inhibitors can abolish phosphorylation at the intracellular carboxyl terminal of c- Met,and then inhibit the recruitment of signal convertors and downstream signaling pathways,which finally achieve anti- tumor activities. Based on the carcinogenic activity of c- Met in HCC,this paper points out that selective inhibitors of c- Met hold promise for targeted therapies for HCC.

     

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