Obesity and related metabolic syndromes are prevalent on the global scale. Thus far,non- alcoholic fatty liver( NAFL) disease has caused wide attention from domestic and overseas scholars. NAFL cirrhosis is considered to be the central part and inevitable stage of liver cirrhosis developed from simple fatty liver and non- alcoholic steatohepatitis. The effect of Hedgehog signaling pathway on hepatocytes in the progression of NAFL fibrosis was elucidated and investigated by a population study. Results showed that abnormal activation of the Hedgehog signaling pathway promoted the progression of NAFL fibrosis. In- depth study on the Hedgehog signaling pathway may provide a new approach for the treatment of NAFL fibrosis.
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