Liver fibrosis is an essential stage in the progression of chronic liver disease to liver cirrhosis,and its incidence is high in the world. The mechanism of liver fibrosis that involves many cytokines and signaling pathways is complicated and is understood by people more and more clearly. This review presents that nuclear factor- erythroid 2- related factor- 2( Nrf2)- mediated antioxidant response plays a critical role in suppressing the progression of liver fibrosis. In addition,autophagy is also an important and complex regulator of liver fibrosis in different pathways. The possible mechanism of interaction between Nrf2 and autophagy in liver fibrosis is also described in this review.Currently,the research combining Nrf2 and autophagy is considered the future direction for the study of liver fibrosis,providing a new idea for the treatment of liver fibrosis.
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