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CN 22-1108/R
Issue 10
Oct.  2014
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Article Navigation >  Journal of Clinical Hepatology  > 2014  >  30(10): 1067-1070

Clinical efficacy of puerarin combined with compound ammonium glycyrrhetate S in treatment of alcoholic hepatitis

DOI: 10.3969/j.issn.1001-5256.2014.10.023

  • The 97th Hospital of PLA

Research funding:

 

  • Received Date: 2014-07-28
  • Published Date: 2014-10-20
    Abstract

  • Objective To investigate the clinical efficacy of puerarin combined with compound ammonium glycyrrhetate S in the treatment of alcoholic hepatitis. Methods A total of 92 patients with alcoholic hepatitis who were admitted to our hospital from February 2011 to February 2014 were recruited in this study and randomly divided into two groups. The control group ( n = 46) was treated with conventional therapy combined with compound ammonium glycyrrhetate S. The test group ( n = 46) was treated with puerarin in addition to the regimen used in the control group. After 20 days of treatment, the levels of total bilirubin ( TBil) , alanine aminotransferase ( ALT) , aspartate aminotransferase ( AST) , glutamyl transpeptidase ( GGT) , albumin ( Alb) , Glasgow alcoholic hepatitis score ( GAHS) , and abdominal ultrasound were measured and compared with the results before the treatment in both groups. The clinical efficacy and adverse reactions in the two groups were also compared. Results After the treatment, the GAHSs and levels of TBil, ALT, AST, and GGT in the two groups were all significantly lower than those before the treatment ( all P < 0. 05) . In the test group after the treatment, the levels of TBil ( 20. 96 ± 6. 85μmol/L) , ALT ( 33. 72 ±14. 18 U/L) , and AST ( 38. 69 ±6. 38 U/L) were all significantly lower than those in the control group ( all P<0. 05) . The marked response rate, overall response rate, and rate of improvement in abdominal ultrasound in the test group were 63. 04%, 93. 48%, and 44. 44%, respectively, all significantly higher than those in the control group ( all P < 0. 05) . There was no significant difference in adverse reactions between the two groups ( P >0. 05) . Conclusion For patients with alcoholic hepatitis, the combined therapy with puerarin and compound ammonium glycyrrhetate S can improve the treatment outcome and protect the liver function, and it has high safety and holds promise for clinical application.

     

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