中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 9
Sep.  2014
Turn off MathJax
Article Contents

Application of proteomics in study of hepatocellular carcinoma

DOI: 10.3969/j.issn.1001-5256.2014.09.030
Research funding:

 

  • Received Date: 2014-01-07
  • Published Date: 2014-09-20
  • Hepatocellular carcinoma ( HCC) is one of the most fatal malignant tumors worldwide. As an important part of cutting- edge research fields, proteomics has been widely used in the studies of related diseases and has currently become a crucial experimental approach to research on HCC. Significantly expressed proteins can be identified as potential biomarkers for early diagnosis and targets for therapeutic drugs for HCC. Moreover, they can be used for prediction of the recurrence and prognosis of HCC, as well as for investigation of pathogenesis of the disease. The proteomic results from worldwide clinical studies of HCC are summarized, and it is suggested that the clinical application of results of basic research on HCC proteomics will bring great benefit to the diagnosis and treatment of HCC.

     

  • loading
  • [1] EL-SERAG HB, RUDOLPH KL.Hepatocellular carcinoma:Epidemiology and molecular carcinogenesis[J].Gastroenterology, 2007, 132 (7) :2557-2576.
    [2]World Health Organization Mortality Database.WHO Statistical Information System[EB/OL].[2014-01-07].http://www.who.int/whosis/en/.
    [3]KASSAHUN WT, FANGMANN J, HARMS J, et al.Liver resection and transplantation in the management of hepatocellular carcinoma:a review[J].Exp Clin Transplant, 2006, 4 (2) :549-558.
    [4] ARRELL DK, NEVEROVA I, van EYK JE.Cardiovascular proteomics:evolution and potential[J].Circ Res, 2001, 88 (8) :763-773.
    [5] WIERZBA K, MUROI M, OSADA H.Proteomics accelerating the identification of the target molecule of bioactive small molecules[J].Curr Opin Chem Biol, 2011, 15 (1) :57-65.
    [6]RIFAI N, GILLETTE MA, CART SA.Protein biomarker discovery and validation:the long and uncertain path to clinical utility[J].Nat Biotechnol, 2006, 24 (8) :971-983.
    [7]KANG XN, SUN L, GUO K, et al.Serum protein biomarkers screening in HCC patients with liver cirrhosis by ICAT-LC-MS/MS[J].J Cancer Res Clin Oncol, 2010, 136 (8) :1151-1159.
    [8]JIN GZ, DONG H, YU WL, et al.A novel panel of biomarkers in distinction of small well-differentiated HCC from dysplastic nodules and outcome values[J].BMC Cancer, 2013, 13:161.
    [9]TSAI ST, TSOU CC, MAO WY, et al.Label-free quantitative proteomics of CD133-positive liver cancer stem cells[J].Proteome Sci, 2012, 10 (1) :69.
    [10] YEO M, NA YM, KIM DK, et al.The loss of phenol sulfotransferase-1 in hepatocellular carcinogenesis[J].Proteomics, 2010, 10 (2) :266-276.
    [11]SUN S, POON RT, LEE NP, et al.Proteomics of hepatocellular carcinoma:serum vimentin as a surrogate marker for small tumors (≤2 cm) [J].J Proteome Res, 2010, 9 (4) :1923-1930.
    [12]LI N, LONG Y, FAN X, et al.Proteomic analysis of differentially expressed proteins in hepatitis B virus-related hepatocellular carcinoma tissues[J].J Exp Clin Cancer Res, 2009, 28:122.
    [13]KANMURA S, UTO H, SATO Y, et al.The complement component C3a fragment is a potential biomarker for hepatitis C virus-related hepatocellular carcinoma[J].J Gastroenterol, 2010, 45 (4) :459-467.
    [14]WANG X, CHEN Y, HAN QB, et al.Proteomic identification of molecular targets of gambogic acid:role of stathmin in hepatocellular carcinoma[J].Proteomics, 2009, 9 (2) :242-253.
    [15]GOU L, WANG W, TONG A, et al.Proteomic identification of RhoA as a potential biomarker for proliferation and metastasis in hepatocellular carcinoma[J].J Mol Med (Berl) , 2011, 89 (8) :817-827.
    [16]REN F, WU H, LEI Y, et al.Quantitative proteomics identification of phosphoglycerate mutase 1 as a novel therapeutic target in hepatocellular carcinoma[J].Mol Cancer, 2010, 9:81.
    [17]HU MY, LAM CT, LIU KD.Proteomic identification of a monoclonal antibody recognizing caveolin-l in hepatocellular carcinoma with metastatic potential[J].Protein Pept Lett, 2009, 16 (5) :479-485.
    [18]LIU H, FU X, JI W, et al.Human sulfatase-1 inhibits the migration and proliferation of SMMC-7721 hepatocellular carcinoma cells by downregulating the growth factor signaling[J].Hepatol Res, 2013, 43 (5) :516-525.
    [19]WU L, PENG CW, HOU JX, et al.Coronin-1C is a novel biomarker for hepatocellular carcinoma invasive progression identified by proteomics analysis and clinical validation[J].J Exp Clin Cancer Res, 2010, 29:17.
    [20]LI Y, WUJ, ZHANGW, et al.Identificationof serumCCL15inhepatocellular carcinoma[J].Br J Cancer, 2013, 108 (1) :99-106.
    [21]ZHAO P, ZHANG W, WANG SJ, et al.HAb18G/CD147 promotes cell motility by regulating annexin ii-activated RhoA and Rac1 signaling pathways in hepatocellular carcinoma cells[J].Hepatology, 2011, 54 (6) :2012-2024.
    [22]YOKOO H, KONDO T, OKANO T, et al.Protein expression associated with early intrahepatic recurrence of hepatoeellular carcinoma after curative surgery[J].Cancer Sci, 2007, 98 (5) :665-673.引证本文:WANG JG, FEI XY, SONG Q.Application of proteomics in study of hepatocellular carcinoma[J].J Clin Hepatol, 2014, 30 (9) :958-960. (in Chinese) 王建钢, 费新应, 宋青.蛋白质组学研究技术在肝细胞癌诊疗中的应用[J].临床肝胆病杂志, 2014, 30 (9) :958-960.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (2595) PDF downloads(532) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return