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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 9
Sep.  2014
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Article Contents

Improving understanding of liver immune function and enhancing research on cell therapy for liver diseases

DOI: 10.3969/j.issn.1001-5256.2014.09.001
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  • Received Date: 2014-07-30
  • Published Date: 2014-09-20
  • As an important immune organ, the liver has a unique immune microenvironment, and is one of the important places for innate immunity and adaptive immunity. The liver is closely connected with the immune system through the gut- liver axis and is also the target organ of immune injury. However, the defensive role of the liver for Hepadnaviridae remains unclear. Cell therapy for liver diseases includes input of liver cells or stem cells for functional replacement, therapy by immune cells for antiviral and antitumor purposes, and genetic therapy for hereditary hepatopathy with cells as the carrier. The features of mesenchymal stem cells, multi- directional differentiation potential and immunomodulatory property, become the hot spots of cell therapy for liver diseases, and efficient in vitro amplification of cells makes it possible for the use of NK cells in the treatment of hepatocellular carcinoma.

     

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