中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 8
Aug.  2014
Turn off MathJax
Article Contents

Application of metabolomics in research on biomarkers for hepatocellular carcinoma

DOI: 10.3969/j.issn.1001-5256.2014.08.039
Research funding:

 

  • Received Date: 2013-08-20
  • Published Date: 2014-08-20
  • As a novel research tool, metabolomics technology can reveal the differences in metabolic profiles during the development and progression of hepatocellular carcinoma (HCC) , so it has been widely applied for research on HCC biomarkers.The significance of metabolomics in the diagnosis of HCC is briefly described, and the metabolomics research aiming at the discovery of HCC biomarkers, including animal experiments and clinical studies of metabolites in the serum, urine, and liver tissue, is reviewed.It is pointed out that analyzing and monitoring metabolites in the development and progression of HCC is of great significance for individualized treatment.

     

  • loading
  • [1]El-SERAG HB, RUDOLPH KL.Hepatocellular carcinoma:edemiology and molecular carcinogenesis[J].Gastroenterology, 2007, 132 (7) , 2557-2576.
    [2]World Health Organization Mortality Database.WHO statistical information system[S/OL].2008[2013-08-20].http://www.who.int/whosis/en/.
    [3]KASSAHUN WT, FANGMANN J, HARMS J, et al.Liver resection and transplantation in the management of hepatocellular carcinoma:a review[J].Exp Clin Transplant, 2006, 4 (2) :549-558.
    [4]CHO WC.Conquering cancer through discovery research[J].IUBMB Life, 2010, 62 (9) :655-659.
    [5]CHO WC.Molecular diagnostics for monitoring and predicting therapeutic effect in cancer[J].Expert Rex Mol Diagn, 2011, 11 (1) :9-12.
    [6]SEGAL E, KIM SK.The modular era of functional genomics[J].Genome Biol, 2003, 4 (5) :317.
    [7]KIM YS, MARUVADA P.Frontiers in metabolomics for cancer research:Proceedings of a National Cancer Institute workshop[J].Metabolomics, 2008, 4 (2) :105-113.
    [8]NICHOLSON JK, LINDON JC, HOLMES E.Metabonomics:understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data[J].Xenobiotica, 1999, 29 (11) :1181-1189.
    [9]NICHOLSON JK, LINDON JC.Systems biology:Metabonomics[J].Nature, 2008, 455 (7216) :1054-1056.
    [10]NICHOLSON JK, CONNELLY J, LINDON JC, et al.Metabonomics:a platform for studying drug toxicity and gene function[J].Nat Rev Drug Discov, 2002, 1 (2) :153-161.
    [11]TAILOR J, KING RD, AHMANN T.Application of metabolomics to plant genotype discrimination using statistics and machine learning[J].Bioinformatics, 2002, 18 (Suppl 2) :241-248.
    [12]ZHU W, LI M, JIN MC.Clinical features of primary hepatic carcinoma:an analysis of 90 cases[J].J Clin Hepatol, 2013, 29 (6) :499-461. (in Chinese) 朱伟, 李明, 金满春.90例原发性肝癌临床特点分析[J].临床肝胆病杂志, 2013, 29 (6) :449-466.
    [13]HENRY CM.New'ome'in town[J].Chem Eng New, 2002, 804 (8) :66-67.
    [14]NG DJY, PASIKANTI KK, CHANECY.Trend analysis of metabonomics and systematic review of metabonomics-derived cancer marker metabolites[J].Metabolomics, 2011, 7 (2) :155-178.
    [15]XIAO ZH, LI J.Application of metabolomics in study on hepatocellular carcinoma[J].Chin J Biologicals, 2012, 25 (7) :929-931. (in Chinese) 肖忠华, 李晶.代谢组学在肝细胞癌研究中的应用[J].中国生物制品学杂志, 2012, 25 (7) :929-931.
    [16]ZHAO H, LIAO J, LIU Y, et al.alpha-fetoprotein and primary hepatic carcinoma[J].J Clin Hepatol, 2008, 24 (5) :385-387. (in Chinese) 赵恒, 廖静, 刘瑜, 等.甲胎蛋白与肝癌[J].临床肝胆病杂志, 2008, 24 (5) :385-387.
    [17]GU JR.Primary liver cancer:challenges and perspectives[M].London:Springer London, Limited, 2012:160.
    [18]LI ZF, WANG J, CHEN H, et al.Gas chromatography/time-offlight mass spectrometry-based metabonomics of hepatocarcinoma in rats with lung metastasis:elucidation of the metabolic characteristics of hepatocarcinoma at formation and metastasis[J].Rapid Commun Mass Spectrom, 2010, 24 (18) :2765-2775.
    [19]TAN YX, YIN PY, TANG L.Metabolomics study of stepwise hepatocarcinogenesis from the model rats to patients:potential biomarkers effective for small hepatocellular carcinoma diagnosis[J].Mol Cell Proteomics, 2012, 11 (2) :m111.
    [20]CHEN F, XUE J, ZHOU L, et al.Identification of serum biomarkers of hepatocarcinoma through liquid chromato-graphy/mass spectrometry-based metabonomic method[J].Anal Bioanal Chem, 2011, 401 (6) :1899-1904.
    [21]CHEN TL, XIE GX, WANG XY.Serum and urine metabolite profiling reveals potential biomarkers of human hepatocellular carcinoma[J].Mol Cell Proteomics, 2011, 10 (7) :m110.
    [22]ZHOU LN, WANG QC, YIN PY, et al.Serum metabolomics reveals the deregulation of fatty acids metabolism in hepatocellular carcinoma and chronic liver diseases[J].Anal Bioanal Chem, 2012, 403 (1) :203-213.
    [23]GAO H, LU Q, LIU X, et al.Application of 1H NMR-based metabonomics in the study of metabolic profiling of human hepatocellular carcinoma and liver cirrhosis[J].Cancer Sci, 2009, 100 (4) :782-785.
    [24]WU H, XUE R, DONG L, et al.Metabolic profiling of human urine in hepatocellular carcinoma patients using gaschromatography/mass spectrometry[J].Anal Chim Acta, 2009, 648 (1) :98-104.
    [25]YANG J, XU G, ZHENG Y, et al.Diagnosis of liver cancer using HPLC-based metabonomics avoiding false-positive result from hepatitis and hepatocirrhosis diseases[J].J Chromatogr B Analyt Technol Biomed Life Sci, 2004, 813 (1-2) :59-65.
    [26]YANG Y, LI C, NIE X, et al.Metabonomic studies of human hepatocellular carcinoma using high-resolution magic-angle spinning1H NMR spectroscopy in conjunction with multivariate data analysis[J].J Proteome Res, 2007, 6 (7) :2605-2614.
    [27]HUANG Q, TAN Y, YIN P, et al.Metabolic characterization of hepatocellular carcinoma using nontargeted tissue metabolomics[J].Cancer Res, 2013, 73 (16) :4992-5002.
    [28]ZHOU HG, CHEN HB, YU XY, et al.Application of metabolomics in early diagnosis of malignant tumors[J].Jilin Univ:Med Edit, 2013, 39 (1) :184-187. (in Chinese) 周红光, 陈海彬, 俞晓忆, 等.代谢组学在恶性肿瘤早期诊断中的应用[J].吉林大学学报:医学版, 2013, 39 (1) :184-187.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (3045) PDF downloads(501) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return