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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 8
Aug.  2014
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Article Contents

Pathogenetic mechanism of microcirculatory disturbance and treatment advances in acute pancreatitis

DOI: 10.3969/j.issn.1001-5256.2014.08.033
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  • Received Date: 2014-07-14
  • Published Date: 2014-08-20
  • In recent years, there has been increasing evidence that microcirculatory disturbance, including vasoconstriction, shunting, inadequate perfusion, increased blood viscosity, and coagulation, is closely associated with the pathogenesis of acute pancreatitis (AP) .These processes may be exacerbated by ischaemia- reperfusion injury and the generation of oxygen radicals.The anatomical features of pancreatic microcirculation, the pathophysiological mechanism of pancreatic microcirculation disturbance and related inflammatory mediators, and progress in the treatment of microcirculatory disturbance in AP are reviewed.It is suggested that the pancreatic and systemic microcirculation may play a key role in the development and progression of AP.

     

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