Objective To investigate the early changes in hemorheological parameters and thromboxane A2 ( TXA2) and prostacyclin ( PGI2) levels among patients with severe acute pancreatitis ( SAP) . Methods Thirty-two SAP patients hospitalized from January 2012 to September 2013 were selected as SAP group; 30 healthy controls were selected as normal control ( NC) group. Venous blood was collected after admission and before treatment. The hemorheological parameters and plasma levels of TXA2and PGI2were determined, and TXA2/PGI2ratio was calculated. Comparison between groups was made by t test. Results Compared with the NC group, the SAP group had a significantly lower erythrocyte deformation index ( t = 2. 185, P < 0. 05) , significantly higher whole blood viscosities at high-, middle-, and low- shear rates and plasma viscosity ( t = 2. 820, 2. 755, 2. 700, and 3. 622, P < 0. 05) , significantly higher whole blood reduced viscosities at high- and low- shear rates ( t = 3. 391 and 2. 018, P < 0. 05) , a significantly higher hematocrit ( t = 2. 980, P < 0. 05) , a significantly higher erythrocyte rigidity index ( t = 2. 209, P < 0. 05) , a significantly higher erythrocyte aggregation index ( t = 2. 004, P < 0. 05) , a significantly higher whole blood relative index at high shear rate ( t = 2. 630, P < 0. 05) , a significantly higher whole blood relative index at low shear rate ( t = 2. 440, P < 0. 05) , a significantly higher TXA2level ( t = 3. 256, P < 0. 05) , a significantly higher PGI2level ( t =2. 589, P < 0. 05) , and a significantly higher TXA2/PGI2ratio ( t = 2. 640, P < 0. 05) . Conclusion Hemorheological disorders and increased activity of vascular endothelial cells appear in the early stage in SAP.
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