The pathogenesis of hyperlipidemic acute pancreatitis caused by pancreatic duct hypertension

Jiachen FENG; Ping ZHANG

doi:10.12449/JCH240134

Volume 40 Issue 1

Jan. 2024

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Article Navigation > Journal of Clinical Hepatology > 2024 > 40(1): 204-207

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The pathogenesis of hyperlipidemic acute pancreatitis caused by pancreatic duct hypertension

DOI: 10.12449/JCH240134

Jiachen FENG,
Ping ZHANG^{,
,}

First Department of Hepatopancreatobiliary Surgery，Center of General Surgery，The First Hospital of Jilin University，Changchun 130021，China

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Corresponding author: ZHANG Ping， z_ping@jlu.edu.cn （ORCID： 0000-0003-4944-2937）
Received Date: 2023-09-27
Accepted Date: 2023-11-24
Published Date: 2024-01-23

Abstract

Abstract

Compared with acute pancreatitis caused by other factors， hyperlipidemic acute pancreatitis often has a higher rate of severe conditions， greater difficulties in predicting prognosis， and a more complex and unclear pathogenesis. At present， the pathogenesis of hyperlipidemic acute pancreatitis may be associated with the elevation of serum free fatty acids， but the lipid-lowering treatment regimens do not reduce the incidence rate of this disease. Recent studies have further confirmed that pancreatic duct hypertension is an important pathogenesis of acute pancreatitis. The latest research advances have shown that hyperlipidemia can lead to pancreatic duct obstruction by causing pancreatic duct hyperplasia， forming protein embolism at the biliary-pancreatic junction， and damaging the secretory function of the pancreatic duct， while pancreatic duct obstruction can in turn cause pancreatic duct obstruction. This article reviews the latest research advances in hyperlipidemia in causing pancreatic duct obstruction and emphasizes that pancreatic duct hypertension is one of the important pathogeneses of hyperlipidemic acute pancreatitis， which will provide new ideas for exploring the pathogenesis of hyperlipidemic acute pancreatitis.
- Pancreatitis,
- Pancreatic duct hypertension,
- Hyperlipidemias

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References(30)

References

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The pathogenesis of hyperlipidemic acute pancreatitis caused by pancreatic duct hypertension

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The pathogenesis of hyperlipidemic acute pancreatitis caused by pancreatic duct hypertension

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