The role and impact of macrophages in the pathogenesis of primary biliary cholangitis

Di MA; Wenlin TAI

doi:10.12449/JCH240126

Volume 40 Issue 1

Jan. 2024

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Article Navigation > Journal of Clinical Hepatology > 2024 > 40(1): 157-160

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The role and impact of macrophages in the pathogenesis of primary biliary cholangitis

DOI: 10.12449/JCH240126

Di MA,
Wenlin TAI^{,
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Department of Clinical Laboratory，The Second Affiliated Hospital of Kunming Medical University，Kunming 650101，China

Research funding:

National Natural Science Foundation of China (82060385);

The Postgraduate Innovation Fund Project of Kunming Medical University 2023 (2023S321)

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Corresponding author: TAI Wenlin， taiwenlin2685@163.com （ORCID： 0000-0002-8278-929X）
Received Date: 2023-03-25
Accepted Date: 2023-04-15
Published Date: 2024-01-23

Abstract

Abstract

Primary biliary cholangitis （PBC） is a chronic autoimmune disease of cholestasis in which immune factors lead to progressive small bile duct destruction， cholestasis， and eventually liver fibrosis， liver cirrhosis， and even liver failure. Macrophages， as a group with functional heterogeneity， play different roles in the whole disease process of PBC. This article summarizes the possible ways by which macrophages are involved in the pathogenesis of PBC and discusses their impact on the disease and the potential therapeutic targets of macrophages. It is pointed out that macrophages are mainly involved in innate immunity in PBC injury and are associated with gut microbiota dysbiosis， and they are also associated with cholestasis， liver fibrosis， and liver cirrhosis in the later stages of the disease.
- Primary Biliary Cholangitis,
- Macrophages,
- Pathologic Processes

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References(33)

References

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The role and impact of macrophages in the pathogenesis of primary biliary cholangitis

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