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Volume 40 Issue 1
Jan.  2024
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Article Navigation >  Journal of Clinical Hepatology  > 2024  >  40(1): 29-32

Establishment and application of animal models for portal vein thrombosis

DOI: 10.12449/JCH240105
  • 1.

    Department of Gastroenterology，General Hospital of Northern Theater Command，Shenyang 110840，China

  • 2.

    Graduate School of China Medical University，Shenyang 110122，China

  • 3.

    Graduate School，Dalian Medical University，Dalian，Liaoning 116044，China

  • 4.

    Department of Gastroenterology，Affiliated Drum Tower Hospital of Nanjing University Medical School，Nanjing 210008，China

Research funding:

National Natural Science Foundation of China (8227034094)

More Information
  • Corresponding author: QI Xingshun， xingshunqi@126.com （ORCID： 0000-0002-9448-6739）
  • Received Date: 2023-11-22
  • Accepted Date: 2023-11-30
  • Published Date: 2024-01-23
    Abstract
  • Portal vein thrombosis （PVT） refers to thromboembolism that occurs in the extrahepatic main portal vein and/or intrahepatic portal vein branches. PVT is the result of the combined effect of multiple factors， but its pathogenesis remains unclear. Animal models are an important method for exploring the pathophysiological mechanism of PVT. Based on the different species of animals， this article reviews the existing animal models of PVT in terms of modeling methods， principles， advantages and disadvantages， and application.

     

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