Potential application of multi-omics techniques in metabolic dysfunction-associated fatty liver disease： From molecular mechanisms to serological markers

Zhenni LIU; Qichen LONG; Min HU

doi:10.12449/JCH250904

Volume 41 Issue 9

Sep. 2025

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Article Navigation > Journal of Clinical Hepatology > 2025 > 41(9): 1737-1743

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Potential application of multi-omics techniques in metabolic dysfunction-associated fatty liver disease： From molecular mechanisms to serological markers

DOI: 10.12449/JCH250904

Zhenni LIU^{1, 2, 3, 4},
Qichen LONG^{1, 2, 3, 4
,
,
,},
Min HU^{1, 2, 3, 4
,
,
,}

1.
Department of Laboratory Medicine，The Second Xiangya Hospital of Central South University，Changsha 410011，China
2.
Hunan Provincial Engineering Research Center for Molecular Diagnostic Technology，Changsha 410011，China
3.
Hunan Provincial Clinical Medical Research Center for Molecular Diagnosis of Infectious Diseases，Changsha 410011，China
4.
Hunan Provincial Clinical Molecular Diagnosis Center，Changsha 410011，China

Research funding:

National Natural Science Foundation of China (82302586)

More Information

Corresponding author: LONG Qichen， qclong@csu.edu.cn （ORCID： 0000-0001-7545-7230）; HU Min， huminjyk@csu.edu.cn （ORCID： 0000-0001-7886-8174）
Received Date: 2025-05-18
Accepted Date: 2025-07-23
Published Date: 2025-09-25

Abstract

Abstract

Metabolic dysfunction-associated fatty liver disease （MAFLD）， formerly known as nonalcoholic fatty liver disease （NAFLD）， has become a common chronic liver disease worldwide. Currently， the clinical methods for diagnosing liver diseases have limitations such as invasive procedures， insufficient sensitivity， and low diagnostic accuracy， posing challenges to the early identification and precise treatment of MAFLD. In recent years， the rapid development of multi-omics techniques has provided new ideas for the precise diagnosis and treatment of MAFLD. Genomics， metabolomics， lipidomics， microbiomics， and proteomics techniques not only offer new insights into the pathogenesis of MAFLD， but also identify novel biomarkers for disease prediction， diagnosis， and staging. Meanwhile， diagnostic models constructed based on multi-omics data have shown good clinical efficacy and laid an important foundation for the development of noninvasive precise diagnostic tools for MAFLD， and therefore， it is expected to realize the transition from traditional diagnosis and treatment to precision medicine. Although the clinical application value of multi-omics markers in the early diagnosis of MAFLD has been recognized to some extent， there are still challenges in clinical translation， such as the standardization of detection， individual heterogeneity， and cost-effectiveness.
- Metabolic Dysfunction-associated Fatty Liver Disease,
- Biomarkers,
- Diagnosis

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References(59)

References

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Potential application of multi-omics techniques in metabolic dysfunction-associated fatty liver disease： From molecular mechanisms to serological markers

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Potential application of multi-omics techniques in metabolic dysfunction-associated fatty liver disease： From molecular mechanisms to serological markers

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