Pathological mechanism of multi-organ injuries in metabolic dysfunction-associated fatty liver disease

Lina JIANG; Jingmin ZHAO

doi:10.12449/JCH250903

Volume 41 Issue 9

Sep. 2025

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Article Navigation > Journal of Clinical Hepatology > 2025 > 41(9): 1729-1736

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Pathological mechanism of multi-organ injuries in metabolic dysfunction-associated fatty liver disease

DOI: 10.12449/JCH250903

Lina JIANG,
Jingmin ZHAO^{,
,}

The Fifth Medical Center of Chinese PLA General Hospital，Beijing 100039，China

Research funding:

National Key RD Program of China (2023YFC2308104);

National Key RD Program of China (2023YFC2308100);

Beijing Hospitals Authority Clinical Medicine Development of Special Funding Support (ZLRK202301);

National Natural Science Foundation of China (92159305)

More Information

Corresponding author: ZHAO Jingmin， jmzhao302@163.com （ORCID： 0000-0003-4345-2149）
Received Date: 2025-07-04
Accepted Date: 2025-08-07
Published Date: 2025-09-25

Abstract

Abstract

Metabolic dysfunction-associated fatty liver disease （MAFLD） and its progressive form， metabolic dysfunction-associated steatohepatitis （MASH）， have emerged as significant types of chronic liver disease worldwide and are closely associated with metabolic syndrome. The liver-extrahepatic organ/tissue axis and the “spill-over effect” of intrahepatic inflammation play pivotal roles in the pathogenesis and progression of MAFLD/MASH， significantly impacting multi-organ metabolic homeostasis and leading to various extrahepatic injuries. These include cardiovascular diseases， sarcopenia， chronic kidney disease， non-alcoholic fatty pancreas disease， polycystic ovary syndrome， hepatocellular carcinoma， and various related solid tumors. There is a notable epidemiological link between MAFLD and the development of both liver cancer and extrahepatic malignancies. The risk of associated tumorigenesis is related to multiple factors， including persistent metabolic disorders， chronic low-grade inflammation， and gut microbiota dysbiosis. Recent research perspectives have shifted from focusing solely on hepatic pathology to recognizing systemic metabolic dysregulation， emphasizing the central role of liver-extrahepatic organ interactions in disease progression. This article aims to explore the pathogenesis of MAFLD/MASH and to review the mechanisms underlying related multi-organ extrahepatic injuries.
- Metabolic Dysfunction-associated Fatty Liver Disease,
- Multi-organ Injuries,
- Pathology

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References

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Pathological mechanism of multi-organ injuries in metabolic dysfunction-associated fatty liver disease

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Pathological mechanism of multi-organ injuries in metabolic dysfunction-associated fatty liver disease

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