李肖，国家癌症中心/中国医学科学院＆北京协和医学院•肿瘤医院•介入治疗科主任兼党支部书记，北京协和医学院、四川大学和中国医科大学博士研究生导师、博士后合作导师；曾任四川大学华西医院介入诊疗中心主任，兼具综合医院和肿瘤专科医院工作与学术背景，擅长门静脉高压及肿瘤相关疾病的微创介入诊疗，专业特长包括以经颈静脉肝内门体分流术（TIPS）为代表的血管性介入治疗、以肿瘤消融和粒子植入为代表的非血管性介入治疗；曾荣登2017-2018年度《中国名医百强榜》门脉高压介入治疗榜首，获得首届人民健康网“国之名医-优秀风范”称号，获选为首批国家卫健委“全国卫生健康技术应用项目-TIPS推广传承人”，获得中华医学科技奖一等奖、四川省科技进步一等奖；担任《中国介入影像与治疗学》杂志主编、《中国临床医师杂志》副主编；主持国家重点研发计划、国家自然科学基金6项；以第一或通讯作者发表SCI论文70余篇；培养博士后、博士和硕士60余人。

发表论文情况：

1.Yan Fu, Chu Hui Zeng, Chao An, Yue Liu, Ji Hoon Shin, Xiao Li. How Biology Guides the Combination of Locoregional Interventional Therapies and Immunotherapy for Hepatocellular Carcinoma: Cytokines and Their Roles. Cancers (Basel). 2023 Feb 19;15(4):1324.

2.Tianhao Cong, Yingen Luo, Yu Li, Chao Yang, Hongcai Yang, Yujie L, Jingui Li, Xiao Li. Cuproptosis-related immune checkpoint gene signature: Prediction of prognosis and immune response for hepatocellular carcinoma. Front Genet. 2022 Oct 5;13:1000997.

3.He Zhao, Jiaywei Tsauo, Xiaowu Zhang, Huaiyuan Ma, Ningna Weng, Zhengqiang Yang, Xiao Li. Prevalence and prognostic impact of hepatopulmonary syndrome in patients with unresectable hepatocellular carcinoma undergoing transarterial chemoembolization: a prospective cohort study. Chin Med J (Engl). 2022 Sep 5;135(17):2043-2048.

4.Chao Yang, Yin-Gen Luo, Hong-Cai Yang, Zhi-Hang Yao, Xiao L. Effects of Early TACE Refractoriness on Survival in Patients with Hepatocellular Carcinoma: A Real-World Study. J Hepatocell Carcinoma. 2022 Jul 21;9:621-631.

5.Yujing Xin, Fei Cao, Hongcai Yang, Xinyuan Zhang, Yi Chen, Xiaojing Cao, Xiang Zhou, Xiao Li, Jinxue Zhou. Efficacy and safety of atezolizumab plus bevacizumab combined with hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma. Front Immunol. 2022 Aug 5;13:929141.

6.Xiaowu Zhang, Yingen Luo, Jiaywei Tsauo, He Zhao, Tao Gong, Jingui Li, Yawei Li, Huiying Zeng, Wei Sun, Xiao Li. Transradial versus transfemoral access without closure device for transarterial chemoembolization in patients with hepatocellular carcinoma: a randomized trial. Eur Radiol. 2022 Oct;32(10):6812-6819.

7.Yuze Li,1,† Ziming Xu,1,† Chao An,2 Huijun Chen,1,* and Xiao Li3,* Multi-Task Deep Learning Approach for Simultaneous Objective Response Prediction and Tumor Segmentation in HCC Patients with Transarterial Chemoembolization. J Pers Med. 2022 Feb; 12(2): 248.

8.Xiaowu Zhang, Jiaywei Tsauo, Jun Tie, Hui Xue, Jian-Bo Zhao, Jian-Jun Li, Zhu-Ting Fang, Wu-Hua Guo, Xiao Li. Emergent Transjugular Intrahepatic Portosystemic Shunt Creation for Acute Gastric Variceal Bleeding in Patients with Hepatocellular Carcinoma. J Vasc Interv Radiol. 2022 Jun;33(6):702-706.

9.He Zhao, Xiaowu Zhang, Jiaywei Tsauo, Jingui Li, Tao Gong, Mingchen San, Xiao L. Comparison of the in vitro clot-capturing efficiencies of commercially available retrievable inferior vena cava filters. J Vasc Surg Venous Lymphat Disord. 2022 Mar;10(2):463-468.e2.

10.He Zhao, Yan Fu, Jiaywei Tsauo, Xiaowu Zhang, Yanqing Zhao, Tao Gong, Jingui Li, Xiao Li. Silver nanoparticle-coated self-expandable metallic stent suppresses tissue hyperplasia in a rat esophageal model. Surg Endosc. 2022 Jan;36(1):66-74.

11.Yan Fu, Tao Gong, Jiaywei Tsauo, Mingchen Sang, He Zhao, Xiaowu Zhang, Jingui Li, Xiao Li. Nintedanib, a multitarget tyrosine kinase inhibitor, suppresses postoperative peritoneal adhesion formation in a rat model. Surgery. 2021 Sep;170(3):806-812.

12.Jiaywei Tsauo, Jun Tie, Hui Xue, Jian-Bo Zhao, Jian-Jun Li, Zhu-Ting Fang, Wu-Hua Guo, Xiao Li. Transjugular Intrahepatic Portosystemic Shunt Creation for the Prevention of Gastric Variceal Rebleeding in Patients with Hepatocellular Carcinoma: A Multicenter Retrospective Study. J Vasc Interv Radiol. 2021 Jul;32(7):963-969.

13.He Zhao, Jiaywei Tsauo, Xiao-Wu Zhang, Huai-Yuan Ma, Ning-Na Weng, Gong-Shun Tang, Xiao Li. Technetium-99m-labeled macroaggregated albumin lung perfusion scan for diagnosis of hepatopulmonary syndrome: A prospective study comparing brain uptake and whole-body uptake. World J Gastroenterol. 2020;26(10):1088-1097.

14.Yanqing Zhao, Xiaowu Zhang, He Zhao, Tao Gong, Jingui Li, Jiaywei Tsauo, Xiao Li. Systemic Therapy Plus Thermal Ablation Versus Systemic Therapy Alone for Oligometastatic Liver Metastases from Non-small Cell Lung Cancer. Cardiovasc Intervent Radiol. 2020;43(9):1285-1293.

15.Tsauo J, Zhao H, Zhang X, Ma H, Jiang M, Weng N, Li X. Changes in arterial oxygenation after portal decompression in Budd-Chiari syndrome patients with hepatopulmonary syndrome. Eur Radiol. 2019;29(6):3273-3280.

16.Tsauo J1, Zhao H1, Zhang X1, Ma H2, Jiang M2, Weng N2, Li X3. Effect of Transjugular Intrahepatic Portosystemic Shunt Creation on Pulmonary Gas Exchange in Patients with Hepatopulmonary Syndrome: A Prospective Study. J Vasc Interv Radiol. 2019;30(2):170-177.

17.Yu J, Wang X, Jiang M, Ma H, Zhou Z, Yang L, Li X. Comparison of transjugular intrahepatic portosystemic shunt (TIPS) alone and combined with embolisation for the management of cardiofundal varices: a retrospective study. Eur Radiol. 2019;29(2):699-706. 

18.Qiu B, Zhang X, Tsauo J, Zhao H, Gong T, Li J, Li X. Transcatheter arterial infusion for pancreatic cancer: a 10-year National Cancer Center experience in 115 patients and literature review. Abdom Radiol (NY). 2019;44(8):2801-2808. 

19.Li X, Tsauo J, Geng C, Zhao H, Lei X, Li X. Ginsenoside Rg3 Decreases NHE1 Expression via Inhibiting EGF-EGFR-ERK1/2-HIF-1 α Pathway in Hepatocellular Carcinoma: A Novel Antitumor Mechanism. Am J Chin Med. 2018;46(8):1915-1931. 

20.Zhao H, Tsauo J, Zhang X, Li X. Regarding "The optimal procedure of modified Rex shunt for the treatment of extrahepatic portal hypertension in children". J Vasc Surg Venous Lymphat Disord. 2018;6(3):421-422.

21.Huang X, Tsauo J, Zhao H, Li X. Re: Immuno-oncology and Its Opportunities for Interventional Radiologists: Immune Checkpoint Inhibition and Potential Synergies with Interventional Oncology Procedures. J Vasc Interv Radiol. 2018;29(4):586.

22.Zhao H, Tsauo J, Zhang X, Ma H, Weng N, Wang L, Li X. Pulmonary transit time derived from pulmonary angiography for the diagnosis of hepatopulmonary syndrome. Liver Int. 2018;38(11):1974-1981. 

23.Tao Z, Yan C, Zhao H, Tsauo J, Zhang X, Qiu B, Zhao Y, Li X. Comparison of endoscopic ultrasonography and magnifying endoscopy for assessment of the invasion depth of shallow gastrointestinal neoplasms: a systematic review and meta-analysis. Surg Endosc. 2017;31(12):4923-4933.

24.Luo X, Wang X, Zhao Y, Ma H, Ye L, Yang L, Tsauo J, Jiang M, Li X. Real-Time 3D CT Image Guidance for Transjugular Intrahepatic Portosystemic Shunt Creation Using Preoperative CT: A Prospective Feasibility Study of 20 Patients. AJR Am J Roentgenol. 2017 Jan;208(1):W11-W16.

25.Deng P, Zhou B, Li X. Risk factors contributing to early infection following transjugular intrahepatic portosystemic shunt in perioperative period. Ann Hepatol. 2016 Sep-Oct;15(5):752-6. 

26.Zhang X, Li X. Successful Embolization of a Huge Hepatic Artery Pseudoaneurysm after Blunt Abdominal Trauma. J Pediatr. 2016;168:252-252.e1.

27.Tsauo J, Li X. Viatorr TIPS Endoprosthesis Versus Generic Expanded Polytetrafluoroethylene-Covered Stent-Grafts. AJR Am J Roentgenol. 2015;205(4): W463. 

28.Zhao H, Tsauo J, Wang X, Li X. Accurate measurement of the normality values of macroaggregated albumin lung perfusion scan in hepatopulmonary syndrome. Ann Nucl Med. 2015t;29(8):754-5.

29.Tsauo J, Weng N, Ma H, Jiang M, Zhao H, Li X. Role of Transjugular Intrahepatic Portosystemic Shunts in the Management of Hepatopulmonary Syndrome: A Systemic Literature Review. J Vasc Interv Radiol. 2015 Sep;26(9):1266-71.

30.Luo X, Ye L, Zhou X, Tsauo J, Zhou B, Zhang H, Zhang X, Li X. C-Arm Cone-Beam Volume CT in Transjugular Intrahepatic Portosystemic Shunt: Initial Clinical Experience. Cardiovasc Intervent Radiol. 2015;38(6):1627-31.

31.Tsauo J, Li X. Portal vein aneurysm associated with Budd-Chiari syndrome treated with transjugular intrahepatic portosystemic shunt: a case report. World J Gastroenterol. 2015;21(9):2858-61. 

32.Wang Z, Zhao H, Wang X, Zhang H, Jiang M, Tsauo J, Luo X, Yang L, Li X. Clinical outcome comparison between TIPS and EBL in patients with cirrhosis and portal vein thrombosis. Abdom Imaging. 2015;40(6):1813-20. 

33.Jiang M, Wang Z, Tsauo J, Li X. Basal ganglia hyperintensity may be a marker of hepatic encephalopathy secondary to portosystemic shunting. Clin Res Hepatol Gastroenterol. 2015;39(1):e5-6.

34.Zhou Y, Tsauo J, Li Y, Li X. Selective Embolization of Systemic Collaterals for the Treatment of Recurrent Hemoptysis Secondary to the Unilateral Absence of a Pulmonary Artery in a Child. Cardiovasc Intervent Radiol. 2015;38(5):1312-5.

35.Tsauo J, Luo X, Ye L, Li X. Three-dimensional path planning software-assisted transjugular intrahepatic portosystemic shunt: a technical modification. Cardiovasc Intervent Radiol. 2015;38(3):742-6.

36.Zhao H, Tsauo J, Ma HY, Li X. The role of macroaggregated albumin lung perfusion scan in hepatopulmonary syndrome: are we ready to draw conclusions? Liver Int. 2015;35(7):1918-9. 

37.Chen 1, Wang W, Tam MD, Quintini C, Fung JJ, Li X. Transjugular intrahepatic portosystemic shunt in liver transplant recipients: indications, feasibility, and outcomes. Hepatol Int. 2015;9(3):391-8.

38.Luo X, Wang Z, Tsauo J, Zhou B, Zhang H, Li X.  Advanced Cirrhosis Combined with Portal Vein Thrombosis: A Randomized Trial of TIPS versus EndoscopicBand Ligation Plus Propranolol for the Prevention of Recurrent Esophageal Variceal Bleeding. Radiology. 2015; 276(1):286-93.

39.Luo X, Nie L, Zhou B, Yao D, Ma H, Jiang M, Zhang H, Li X. Transjugular intrahepatic portosystemic shunt for the treatment of portal hypertension in noncirrhotic patients with portal cavernoma. Gastroenterol Res Pract. 2014;2014:659726. doi: 10.1155/2014/659726. 

40.Wang Z, Zhang H, Zhao H, Wang X, Tsauo J, Luo X, Li X. Repeated transcatheter arterial chemoembolization is safe for hepatocellular carcinoma in cirrhotic patients with transjugular intrahepatic portosystemic shunt. Diagn Interv Radiol. 2014;20(6):487-91. 

41.Jiang M, Wang Z, Tsauo J, Li X. Basal ganglia hyperintensity may be a marker of hepatic encephalopathy secondary to portosystemic shunting. Clin Res Hepatol Gastroenterol. Clin Res Hepatol Gastroenterol. 2015 Feb;39(1):e5-6.

42.Zhou Y, Tsauo J, Li Y, Li X. Selective Embolization of Systemic Collaterals for the Treatment of Recurrent Hemoptysis Secondary to the Unilateral Absence of a Pulmonary Artery in a Child. Cardiovasc Intervent Radiol. 2015 Oct;38(5):1312-5.

43.Tsauo J, Yu Y, Luo X, Wang Z, Liu L, Li X. Direct intrahepatic portocaval shunt creation via the inter-strut space of the inferior vena cava stent. Clin Radiol. 2014 Sep;69(9):896-9. 

44.Yu Y, Zhang C, Liu L, Li X. Hepatic arterial administration of ginsenoside Rg3 and transcatheter arterial embolization for the treatment of VX2 liver carcinomas. Exp Ther Med. 2013;5:761-766.

45.Tsauo J, Yang D, Ma H, Li X. Traumatic Inferior Gluteal Artery Pseudoaneurysm with Compressive Neuropathy Managed with Endovascular Embolization and Surgery. Cardiovasc Intervent Radiol. 2014;37(1):275-7.

46.Tsauo J, Liu L, Li X. Hepatobiliary and pancreatic: transient hepatic ischemia caused by acute portal vein thrombosis. J Gastroenterol Hepatol. 2013;28(9):1433. 

47.Tsauo J, Liu L, Tang C, Li X. Education and Imaging. Hepatobiliary and pancreatic: spontaneous intrahepatic portosystemic shunt associated with cirrhosis. J Gastroenterol Hepatol. 2013;28(6):904. 

48.Tsauo J, Liu L, Li X. Hepatobiliary and pancreatic: transient hepatic ischemia caused by acute portal vein thrombosis. J Gastroenterol Hepatol. 2013;28:1433.

49.Tsauo J, Li X, Li H, Wei B, Luo X, Zhang C, Tang C. Transjugular insertion of bare-metal biliary stent for the treatment of distal malignant obstructive jaundice complicated by coagulopathy. Cardiovasc Intervent Radiol. 2013;36:521-525.

50.Luo XF, Nie L, Wang Z, Tsauo J, Liu LJ, Yu Y, Zhou B, Li X. Stent-grafts for the treatment of TIPS dysfunction: fluency stent vs Wall graft stent. World J Gastroenterol. 2013;19:5000-5005.

51.Luo X, Nie L, Wang Z, Tsauo J, Tang C, Li X. Transjugular Endovascular Recanalization of Splenic Vein in Patients with Regional Portal Hypertension Complicated by Gastrointestinal Bleeding. Cardiovasc Intervent Radiol. 2014 Feb;37(1):108-13.

52.Luo X, Nie L, Tsauo J, Wang Z, Tang C, Li X. Parallel shunt for the treatment of transjugular intrahepatic portosystemic shunt dysfunction. Korean J Radiol 2013;14:423-429.

53.Chen S, Li X, Wei B, Tong H, Zhang MG, Huang ZY, Cao JW. Recurrent variceal bleeding and shunt patency: prospective randomized controlled trial of transjugular intrahepatic portosystemic shunt alone or combined with coronary vein embolization. Radiology. 2013;268:900-906.

54.Zhang C, Liu L, Yu Y, Chen B, Tang C, Li X. Antitumor effects of ginsenoside Rg3 on human hepatocellular carcinoma cells. Mol Med Rep. 2012;5:1295-1298.

55.Wang Z, Yu Y, Yang W, Chen B, Li X. Does Helicobacter pylori eradication really reduce the risk of gastric cancer at the population level? Gut. 2013 Jun;62(6):950.

56.Nie L, Luo XF, Li X. Gastrointestinal bleeding caused by extrahepatic arterioportal fistula associated with portal vein thrombosis. World J Gastroenterol. 2012;18:6501-6503.

57.Liu L, Yu Y, Zhang C, Luo X, Tsauo J, Tang C, Li X. Education and Imaging. Hepatobiliary and pancreatic: hepatocellular carcinoma supplied by portal blood after repeated transcatheter arterial chemoembolization. J Gastroenterol Hepatol. 2012;27:1408.

58.Liu L, Yu Y, Jin X, Wang Z, Li X. Management of superior mesenteric arteriovenous fistula after small bowel resection 20 years previously: endovascular treatment. Can J Gastroenterol. 2012;26:864-865.

59.Chen B, Tang CW, Zhang CL, Cao JW, Wei B, Li X. Melena-associated regional portal hypertension caused by splenic arteriovenous fistula. World J Gastroenterol. 2012;18:1996-1998.

60.Tsauo J, Luo X, Ye L, Li X. Three-Dimensional Path Planning Software-Assisted Transjugular Intrahepatic Portosystemic Shunt: A Technical Modification. Cardiovasc Intervent Radiol. 2014 Jun 17. [Epub ahead of print] PMID: 24934737.

61.Yao D, Kunam VK, Li X.A review of the clinical diagnosis and therapy of cholangiocarcinoma. J Int Med Res. 2014;42(1):3-16.

62.Yao D, Luo X, Zhou B, Li X. Ileal conduit stomalvariceal bleeding managed by endovascular embolization. World J Gastroenterol. 2013; 19(44): 8156–8159.

63.Luo X, Nie L, Wang Z, Tsauo J, Tang C, Li X. Transjugular endovascular recanalization of splenic vein in patients with regional portal hypertension complicated by gastrointestinal bleeding. Cardiovasc Intervent Radiol. 2014 Feb;37(1):108-13. 

64.Tsauo J, Yang D, Ma H, Li X. Traumatic inferior gluteal artery pseudoaneurysm with compressive neuropathy managed with endovascular embolization and surgery. Cardiovasc Intervent Radiol. 2014 Feb;37(1):275-7. 

65.Li X, Li F, Wei B, Li B, Tang CW. Small-for-size syndrome after living donor liver transplantation: successful treatment with a transjugular intrahepatic portosystemic shunt. Liver Transpl. 2012;18:1118-1120.

66.Liu L, Yu Y, Zhang C, Luo X, Tsauo J, Tang C, Li X. Education and Imaging. Hepatobiliary and pancreatic: hepatocellular carcinoma supplied by portal blood after repeated transcatheter arterial chemoembolization. J Gastroenterol Hepatol. 2012;27(8):1408. 

67.Li X, Tang CW. An obscure mass in the head of the pancreas of an adolescent. Gut. 2011;60(8):1086, 1138. 

68.Li X, Li HC, Tang CW. Endovascular embolization for gastrointestinal bleeding caused by splenic arteriovenous fistula. Chin Med J (Engl) 2010;123:2616-2618.

69.Li X, Zhou X, Guan Y, Wang YX, Scutt D, Gong QY. N-nitrosodiethylamine-induced pig liver hepatocellular carcinoma model: radiological and histopathological studies. Cardiovasc Intervent Radiol. 2006;29(3):420-8.

70. Li X, Wang YX, Zhou X, Guan Y, Tang C. Catheterization of the hepatic artery via the left common carotid artery in rats. Cardiovasc Intervent Radiol. 2006;29(6):1073-6.

71.Li X, Zhou XP, Guan YS, Wang YX. Magnetic resonance imaging of hepatocellular carcinoma induced by diethylnitrosamine in Sprague-Dawley rats. Hepatobiliary Pancreat Dis Int. 2005 Aug;4(3):427-32.

基金项目（主持）：

1.经颈静脉肝内门体静脉分流术关键穿刺套件研发，北京市科技计划

2.金纳米颗粒涂层支架光热效应预防大鼠气道支架植入后支架相关狭窄的实验研究，国家自然科学基金面上项目

3.糖代谢异常在肝癌介入中的作用及治疗研究，国家自然科学基金面上项目

4.基于增强现实导航的肺癌介入诊治一体化关键技术研究，国家重点研发计划

5.经皮脾肾分流术治疗肝硬化门脉高压症的实验研究，国家自然科学基金面上项目 

6.门静脉栓塞选择性诱导肝叶增生的实验研究，国家自然科学基金面上项目

7.动脉栓塞联合非细胞毒性药物治疗大鼠肝癌的实验研究，国家自然科学基金面上项目

获奖情况：

1. 门静脉高压介入诊疗关键技术研究与应用，中华医学科技奖，一等奖（排名第一）

2. 肝硬化门静脉高压发病机制及治疗关键技术的研究与应用，四川省科学技术进步奖，一等奖（排名第二）

获得专利情况：

授权号：CN 109259827 B

发明名称：手术套件以及穿刺针套件、穿刺针套件的加工方法